TY  - BOOK
AU  - Verdier,Jean-Michel
TI  - Prions and prion diseases: new developments 
T2  - Protein biochemistry, synthesis, structure, and cellular functions
SN  - 9781619427686
AV  - QR502 
U1  - 573.8/639929 23
PY  - 2012///]
CY  - New York
PB  - Nova Biomedical/Nova Science Publishers, Inc.
KW  - Prions
KW  - Prion diseases
KW  - Prions (Virologie)
KW  - Maladies à prions
KW  - SCIENCE
KW  - Life Sciences
KW  - Biology
KW  - bisacsh
KW  - Microbiology
KW  - fast
KW  - Electronic books
N1  - Includes bibliographical references and index; PRIONS AND PRION DISEASES -- PRIONS AND PRION DISEASES -- CONTENTS -- PREFACE -- NEUROPATHOLOGY OF HUMAN PRION DISEASES -- ABSTRACT -- INTRODUCTION -- THE ROLE OF NEUROPATHOLOGY -- PERFORMING THE AUTOPSY -- NEUROPATHOLOGICAL EXAMINATION -- A.) Macroscopy -- B.) Work-Up for Histological Evaluation -- C.) Microscopic Assessment -- I.) Spongiform Change of the Neuropil -- a) In Sporadic Forms -- b.) In Genetic Forms -- c.) In Acquired Forms -- II) Neuronal Death -- a.) In Sporadic Forms -- b.) In Genetic Forms -- c.) In Acquired Forms; SYNAPTIC PATHOLOGY III.) Astroglial Proliferation -- IV.) Microglial Activation -- V.) PrP Amyloid Plaques -- a.) In Sporadic Forms -- b.) In Genetic Forms -- c.) In Acquired Forms -- VI.) Cerebellar Pathology -- a.) In Sporadic Forms -- b.) In Genetic Forms -- c.) In Acquired Forms -- RELATIVE RESISTANCE OF HIPPOCAMPUS IN CJD -- VII.) Detection of PrP -- VIIa.) By Immunohistochemistry -- a.) In Sporadic Forms -- b.) In Genetic Forms -- c.) In Acquired Forms -- VIIb.) By histoblot and Paraffin-Embedded Tissue Blot; VIId.) By Western blota.) In Sporadic Forms -- b.) In Genetic Forms -- c.) In Acquired Forms -- VIII.) Co-deposition of other Abnormal Protein Aggregates in CJD -- a) In Sporadic Forms -- b) In Genetic Forms -- c) In Acquired Forms -- IX.) Differential Diagnoses from Autopsy Series -- X.) Neuronal Systems and Their Clinico-Pathological Correlates -- CONCLUSION -- ACKNOWLEDGMENTS -- REFERENCES -- THE NATURE OF THE INFECTIOUS AGENTS: PRP MODELS OF RESISTANT SPECIES TO PRION DISEASES (DOG, RABBIT AND HORSES) -- Abstract -- 1. Introduction; 2. MaterialsandMethods3. ResultsandDiscussion -- 4. Conclusion -- Acknowledgments -- References -- INDUCING TRANSMISSIBLE PRION DISEASES WITH RECOMBINANT FIBRILS: A NEW CONCEPT ON GENESIS AND EVOLUTION OF INFECTIOUS PRIONS -- ABSTRACT -- GENERATING TRANSMISSIBLE PRION DISEASES DE NOVO -- THE MECHANISM OF TRIGGERING PRION DISEASE BY RPRP AMYLOID FIBRILS -- EXPERIMENTAL EVIDENCE SUPPORT THE SECOND MODEL -- THE HYPOTHESIS OF DEFORMED TEMPLATING -- CONFORMATIONAL SWITCHING WITHIN INDIVIDUAL AMYLOID FIBRILS AND STRAIN ADAPTATION PHENOMENON; CROSS-TALK BETWEEN AMYLOIDOGENIC PROTEINS REFERENCES -- SYNTHETIC PRIONS -- ABSTRACT -- 1. INTRODUCTION -- 2. STRATEGIES FOR DE NOVO MAMMALIAN PRIONS GENERATION -- 2.1. Cell-Free Assay Using Mammalian Prions -- 2.2. De Novo Generation of Prions by Mouse Transgenesis -- 2.3. In Vitro De Novo Prions by PMCA -- 2.4. De Novo Prions by Amyloid Seeding Assay -- 2.5. De Novo Prions by Annealing Technique -- 2.6. Concluding Remarks and New Emerging Techniques for Prion Detection and Generation -- 3. STRUCTURAL BIOLOGY OF NATURAL AND SYNTHETIC PRIONS
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ER  -