TY - BOOK AU - Weber,Violet TI - Intrinsically disordered proteins (IDPs): structural characterization, therapeutic applications and future directions T2 - Protein biochemistry, synthesis, structure, and cellular functions series SN - 9781634844222 AV - QP551 U1 - 572/.6 23 PY - 2016///] CY - New York PB - Nova Publishers KW - Proteins KW - Structure KW - Conformation KW - Intrinsically Disordered Proteins KW - chemistry KW - Protein Conformation KW - Protéines KW - SCIENCE / Life Sciences / Biochemistry KW - bisacsh KW - fast KW - Electronic books N1 - Includes bibliographical references and index; INTRINSICALLY DISORDERED PROTEINS (IDPS): STRUCTURAL CHARACTERIZATION, THERAPEUTIC APPLICATIONS AND FUTURE DIRECTIONS; INTRINSICALLY DISORDERED PROTEINS (IDPS): STRUCTURAL CHARACTERIZATION, THERAPEUTIC APPLICATIONS AND FUTURE DIRECTIONS; Library of Congress Cataloging-in-Publication Data; CONTENTS; PREFACE; Chapter 1: INTRINSIC DISORDER INDNA-BINDING PROTEINS; ABSTRACT; INTRODUCTION; 1. CHROMATIN ARCHITECTURAL PROTEINS; 2. TRANSCRIPTION FACTORS; 3. INTRINSICALLY DISORDERED PROTEINS IN DNA METABOLISM; CONCLUSION; REFERENCES; Chapter 2: STRUCTURAL ANALYSIS OF INTRINSICALLY DISORDERED PROTEINS: COMPUTER ATOMISTIC SIMULATIONAbstract; 1. Introduction; 2. The Tau Protein; 3. Initial Configuration and Dynamical Evolution; 4. Secondary Structures; 5. Tertiary Structures; 6. Fit of Experimental SAXS Data; 7. Transient Structures; 8. Conclusion; Acknowledgment; References; Chapter 3: BIOPHYSICAL CHARACTERIZATION OF INTRINSICALLY DISORDERED PROTEINS AND THEIR COMPLEXES: CHALLENGES AND CONTRADICTIONS; ABSTRACT; INTRODUCTION; DO IDPS FOLD UPON BINDING TO THE CELL MEMBRANE?; DO IDPS DIMERIZE?; CONCLUSION; REFERENCES; INDEX UR - https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=1226111 ER -