TY  - BOOK
AU  - Wodarz,Dominik
AU  - Komarova,Natalia L.
TI  - Dynamics of cancer: mathematical foundations of oncology 
SN  - 9789814566377
AV  - RC254 .W66 2014eb
U1  - 616.99/400285 23
PY  - 2014///
CY  - [Hackensack] New Jersey
PB  - World Scientific
KW  - Oncology
KW  - Mathematics
KW  - Cancer
KW  - Treatment
KW  - Data processing
KW  - Computational biology
KW  - Neoplasms
KW  - Computational Biology
KW  - Cancérologie
KW  - Mathématiques
KW  - Traitement
KW  - Informatique
KW  - Bio-informatique
KW  - HEALTH & FITNESS
KW  - Diseases
KW  - General
KW  - bisacsh
KW  - MEDICAL
KW  - Clinical Medicine
KW  - Evidence-Based Medicine
KW  - Internal Medicine
KW  - fast
KW  - Electronic books
KW  - 7
N1  - Includes bibliographical references and index; 1. Teaching guide -- 2. Cancer and somatic evolution -- 3. Mathematical modeling of tumorigenesis -- 4. Single species growth -- 5. Two-species competition dynamics -- 6. Competition between genetically stable and unstable cells -- 7. Chromosomal instability and tumor growth -- 8. Angiogenesis, inhibitors, promoters, and spatial growth -- 9. Evolutionary dynamics of tumor initiation through oncogenes: the gain-of-function model -- 10. Evolutionary dynamics of tumor initiation through tumor-suppressor genes: the loss-of-function model and stochastic tunneling -- 11. Microsatellite and chromosomal instability in sporadic and familial colorectal cancers -- 12. Evolutionary dynamics in hierarchical populations -- 13. Spatial evolutionary dynamics of tumor initiation -- 14. Complex tumor dynamics in space -- 15. Stochastic modeling of cancer growth, treatment, and resistance generation -- 16. Evolutionary dynamics of drug resistance in chronic myeloid leukemia -- 17. Evolutionary dynamics of stem-cell driven tumor growth -- 18. Tumor growth kinetics and disease progression -- 19. Epigenetic changes and the rate of DNA methylation -- 20. Telomeres and cancer protection -- 21. Gene therapy and oncolytic virus therapy -- 22. Immune responses, tumor growth, and therapy -- 23. Towards higher complexities: social interactions
N2  - The book aims to provide an introduction to mathematical models that describe the dynamics of tumor growth and the evolution of tumor cells. It can be used as a textbook for advanced undergraduate or graduate courses, and also serves as a reference book for researchers. The book has a strong evolutionary component and reflects the viewpoint that cancer can be understood rationally through a combination of mathematical and biological tools. It can be used both by mathematicians and biologists. Mathematically, the book starts with relatively simple ordinary differential equation models, and subsequently explores more complex stochastic and spatial models. Biologically, the book starts with explorations of the basic dynamics of tumor growth, including competitive interactions among cells, and subsequently moves on to the evolutionary dynamics of cancer cells, including scenarios of cancer initiation, progression, and treatment. The book finishes with a discussion of advanced topics, which describe how some of the mathematical concepts can be used to gain insights into a variety of questions, such as epigenetics, telomeres, gene therapy, and social interactions of cancer cells
UR  - https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=787883
ER  -