TY  - BOOK
AU  - Murray,Sean A.
TI  - Animal models in cancer research and human disease: applications, outcomes and controversies 
T2  - Microbiology research andvances
SN  - 9781624175886
AV  - RC268.5 
U1  - 616.0273 23
PY  - 2013///]
CY  - New York
PB  - Nova Biomedical/Nova Science Publishers, Incorporated
KW  - Carcinogenesis
KW  - Animal models
KW  - Diseases
KW  - Animal models in research
KW  - Moral and ethical aspects
KW  - Research
KW  - Disease Models, Animal
KW  - Ethics
KW  - Cancérogenèse
KW  - Modèles animaux
KW  - Maladies
KW  - Modèles animaux dans la recherche
KW  - Aspect moral
KW  - Recherche
KW  - research (function)
KW  - aat
KW  - MEDICAL
KW  - bisacsh
KW  - fast
KW  - Electronic books
KW  - 7
N1  - Includes bibliographical references and index; ANIMAL MODELS IN CANCER RESEARCH AND HUMAN DISEASE ; ANIMAL MODELS IN CANCER RESEARCH AND HUMAN DISEASE ; Contents ; Preface ; Murine Models of Sporadic and Inflammation-Related Colon Carcinogenesis with Particular Focus on the AOM/DSS Chemically Induced Colorectal Cancer Model ; Abstract ; Introduction ; A Variety of CRC Models: Benefits and Limits ; Chemically Induced Colon Carcinogenesis in Rodents ; The AOM/DSS Model in the Study of Colorectal Carcinogenesis ; Histogenesis of Colon Cancer in AOM/DSS Model -- from the Emergence of Precancerous Lesions to Late Carcinomas; Molecular Events Associated with Colon Carcinogenesis in the AOM/DSS Model and Relevance for Human CRC Wnt/APC/Ý-Catenin Pathway ; K-Ras ; c-Myc ; TGF-Ý ; Cox-2 ; iNOS ; p53 Pathway ; Epigenetic Modifications ; Pathogenesis and Molecular Biology of Colitis-Induced Carcinogenesis in the AOM/DSS Model; Proinflammatory Factors ; Regulatory Factors ; Chemokines ; Toll Like Receptors ; TIR8 ; Heparanase ; Oxidative Stress and DNA Damage; The AOM/DSS Model in Preclinical Studies ; Natural Plant Compounds ; Modulation of Physiological Molecules ; Synthetic Drugs ; Conclusion ; Acknowledgment; 3.3. Mechanical Injury Induced Neointimal Hyperplasia 4. Animal Models of Structural Heart Disease ; 4.1. Ischemic Mitral Regurgitation ; Conclusion ; Acknowledgment ; References ; Canine Breast Cancer and Lymphoma as Modelsin Cancer Research ; Abstract ; 1. Introduction ; 1.1. Dogs as Appropriate Animal Models of Human Cancers ; 2. Canine Mammary Tumor Model ; 2.1. Expression Defects of Cell Cycle Regulators in the CMT Model ; Deregulation of p16/INK4A/ARF/INK4B Locus in CMTs ; 2.2. Genome-Wide Comparative Analysis of the Role of Critical Genes Involved in Human and Canine Mammary Tumors; 2.3. Expression of miRNAs in Human Breast Cancer and the CMT Model 3. Canine Lymphoma Model ; Conclusion ; References ; Development of Cell Therapeutic Strategies for Alzheimer's Disease Using Animal Models ; Abstract ; Introduction ; Amyloid Cascade Hypothesis ; Transgenic Mice Models of AD ; Therapeutic Strategies Using Transgenic Mice Models of AD ; Microglia in the AD Brain ; Cell Therapeutic Strategies for AD ; Conclusion ; Acknowledgments ; References ; Animal Models for AntineoplasticChemotherapy-Induced Alopecia; Abstract ; Introduction ; The Biology of the Hair Follicles (HFs)
UR  - https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=570679
ER  -