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DNA Replication Controls

By: Material type: ArticleArticleLanguage: English Publication details: MDPI - Multidisciplinary Digital Publishing Institute 2017Description: 1 electronic resource (X, 304 p.)ISBN:
  • books978-3-03842-569-4
  • 9783038425694
  • 9783038425687
Subject(s): Online resources: Summary: The conditions for DNA replication are not ideal, owing to endogenous and exogenous replication stresses that lead to arrest of the replication fork. Arrested forks are among the most serious threats to genomic integrity because they can break or rearrange, leading to genomic instability, which is a hallmark of cancers and aging-related disorders.
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The conditions for DNA replication are not ideal, owing to endogenous and exogenous replication stresses that lead to arrest of the replication fork. Arrested forks are among the most serious threats to genomic integrity because they can break or rearrange, leading to genomic instability, which is a hallmark of cancers and aging-related disorders.

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