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Chapter 15 Brain Tumors and the Lynch Syndrome

By:

Peltomäki, Päivi [auth]

Contributor(s):

Gylling, Annette [auth]

Material type: Article

ArticleLanguage: English Publication details: InTechOpen 2011ISBN:

21293

Subject(s):

Online resources:

Summary: Lynch syndrome (LS) (MIM No. 120435-6), previously known as hereditary nonpolyposis colorectal cancer (HNPCC) (Boland, 2005), is an autosomal dominant disorder caused by germline mutation in one of the DNA mismatch repair (MMR) genes. LS is among the most prevalent cancer syndromes in man and is estimated to account for 1-6% of all colorectal cancers (Lynch & de la Chapelle, 2003).

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Lynch syndrome (LS) (MIM No. 120435-6), previously known as hereditary nonpolyposis colorectal cancer (HNPCC) (Boland, 2005), is an autosomal dominant disorder caused by germline mutation in one of the DNA mismatch repair (MMR) genes. LS is among the most prevalent cancer syndromes in man and is estimated to account for 1-6% of all colorectal cancers (Lynch & de la Chapelle, 2003).

FP7 Ideas: European Research Council

Creative Commons https://creativecommons.org/licenses/by-nc-sa/3.0/ cc https://creativecommons.org/licenses/by-nc-sa/3.0/

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