The rheumatology handbook / edited by Margaret Callan.

Includes bibliographical references (pages 455-458) and index.

Print version record.

Preface; Contributing Authors; Chapter 1 Basic Science for Rheumatology; 1.1. Introduction; 1.2. Anatomy of Bones and Joints; 1.2.1. Bones; Development of Bones; Microstructure; Macrostructure; Surface Features of Bones; Bone Turnover; Modulatory effectors of osteoblast function; Modulatory effectors of osteoclast function; 1.2.2. Joints; Classification and Function; Articular Surfaces; Cartilage; Fibrous Capsule; Synovial Membrane; Synovial Fluid; Ligaments; Intra-Articular Structures; Movement at Synovial Joints; 1.3. Biochemistry of Crystal Formation; 1.3.1. Sodium Urate Crystals.

1.3.2. Calcium Salt Crystals1.4. Innate and Adaptive Immunity; 1.4.1. Cells of the Innate Immune System; Neutrophils; Eosinophils; Basophils and Mast Cells; Monocytes and Macrophages; Natural Killer Cells; Dendritic Cells; 1.4.2. Soluble Factors in Innate Immunity; Complement Proteins; Acute Phase Proteins; 1.4.3. Cells of the Adaptive Immune System; T Cells; CD4 T cells; CD8 T cells; Regulatory T cells; B Cells; 1.4.4. Soluble Mediators of Adaptive Immunity; Antibodies; 1.4.5. Autoimmunity; Failure of Tolerance; Failure of central tolerance; Failure of peripheral tolerance.

Hypersensitivity, Immunopathology and Autoimmunity1.5. Inflammation; 1.5.1. Angiogenesis; 1.5.2. Leukocyte Trafficking; 1.5.3. Cytokines and Chemokines; Cytokines; TNF- [alpha]; The IL-1 superfamily; The IL-6 family; The IL-17 family; Chemokines; Pleiotropy and Redundancy; 1.6. Genes and Proteins in Rheumatic Disease; 1.6.1. Deoxyribonucleic Acid and Protein; DNA; Genes, Transcription and Translation; 1.6.2. Genetic Disease; Monogenic and Polygenic Diseases; Genetics in Rheumatic Disease; Establishing heritability in polygenic disease; Identifying quantitive trait loci; Candidate gene analysis.

HLA System and Predisposition to Rheumatic DiseasesThe Role of Abnormal Genes in the Pathogenesis of Disease; Chapter 2 Clinical Assessment of Patients with Rheumatic Disease; 2.1. Gait, Arms, Legs, Spine Screen; 2.2. History; Presenting Complaint; Past Medical History; Family History; Social History; Drug History; 2.3. Examination; 2.3.1. The Hand and Wrist; Pathology; Examination; Look; Feel; Move; Further examination; Special tests; 2.3.2. The Elbow; Pathology; Examination; Look; Feel; Move; Further examination; Special tests; 2.3.3. The Shoulder; Pathology; Examination; Look; Feel; Move.

Further examinationSpecial tests; 2.3.4. The Hip; Pathology; Examination; Look; Feel; Move; Further examination; Special Tests; 2.3.5. The Knee; Pathology; Examination; Look; Feel; Move; Further examination; Special tests; 2.3.6. The Ankle and Foot; Pathology; Examination; Look; Feel; Move; Further examination; 2.3.7. The Neck; Pathology; Examination; Look; Feel; Move; Further examination; 2.3.8. The Thoracic and Lumbar Spine; Pathology; Examination; Look; Feel; Move; Further examination; Special tests; 2.3.9. Gait; 2.3.10. Extra-Articular Features of Rheumatic Disease.

The Rheumatology Handbook is a unique resource for medical students and non-specialist doctors. It represents a collaborative effort between specialists from major teaching hospitals within the UK and Ireland, with each chapter being edited by a different consultant rheumatologist with the relevant subspecialty interest. Written clearly and concisely and well illustrated, the book provides readers with the basic scientific information that they require to understand current concepts about the pathogenesis of rheumatological disease, and draws on recent research studies to give up-to-date infor.

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