Experimental Models in Serotonin Transporter Research.

Cover13; -- Contents13; -- List of contributors -- Preface: Focus on the serotonin transporter -- 1 Presynaptic adaptive responses to constitutive versus adult pharmacologic inhibition of serotonin uptake -- 2 Cellular and molecular alterations in animal models of serotonin transporter disruption: a comparison between developmental and adult stages -- 3 Developmental roles for the serotonin transporter -- 4 SERT models of emotional dysregulation -- 5 The serotonin transporter and animal models of depression -- 6 The serotonin transporter knock-out rat: a review -- 7 WistarZagreb 5HT rats: a rodent model with constitutional upregulation/downregulation of serotonin transporter -- 8 The role of the serotonin transporter in reward mechanisms -- 9 Modeling SERT X BDNF interactions in brain disorders: 13;single BDNF gene allele exacerbates brain monoamine deficiencies and increases stress abnormalities in serotonin transporter knock-out mice -- 10 Primate models in serotonin transporter research -- 11 The role of serotonin transporter in modeling psychiatric disorders: focus on depression, emotion regulation, and the social brain -- Index.

The serotonin transporter is a key brain protein that modulates the reuptake of the neurotransmitter serotonin from synaptic spaces back into the presynaptic neuron. This control over neuronal signalling makes it a prime area of neuroscientific study. In this book an international team of top experts introduce and explicate the role of serotonin and the serotonin transporter in both human and animal brains. They demonstrate the relevance of the transporter and indeed the serotonergic system to substrates of neuropsychiatric disorders, and explain how this knowledge is translated into valid animal models that will help foster new discoveries in human neurobiology. Writing for graduate students and academic researchers, they provide a comprehensive coverage of a wide spectrum of data from animal experimentation to clinical psychiatry, creating the only book exclusively dedicated to this exciting new avenue of brain research.

Includes bibliographical references and index.

English.

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