Molecules : nucleation, aggregation and crystallization : beyond medical and other implications / edited by Jan Sedzik, Paolo Riccio.

Includes bibliographical references and index.

From kuru to nucleation, aggregation, polymerization and crystallization in biology and medicine / D. Carleton Gajdusek -- Gels mimicking antibodies in their selective recognition of proteins and its potential use for protein crystallization / Jan Sedzik [and others] -- Bioinformatics of myelin membrane proteins / Gunnar von Heijne and Jan Sedzik -- Biomolecular mass spectrometry : applications to proteins and peptides / Leopold L. Ilag and Gianluca Maddalo -- Myelin : a one-dimensional biological "crystal" for X-ray and neutron scattering / Hideyo Inouye and Daniel A. Kirschner -- Two-dimensional crystallization of biological macromolecules / Hans Hebert -- Crystallization of proteins : principles and methods / Lata Govada -- The role of oil in protein crystallization / Naomi E. Chayen -- Introduction to crystallization of fine chemicals and pharmaceuticals / Åke C. Rasmuson -- Myelin basic protein, a saucy molecule with high responsiveness to the environment or just an unusual membrane protein? / Paolo Riccio -- The use of a magnetic field and magnetic force as a means to improve the quality of protein crystals / Mitsuo Ataka -- Interactive crystallomic / Jan Sedzik -- Virtual molecule : P0 myelin glycoprotein. I. homology modeling and prediction of the secondary and tertiary structure / Jan Pawel Jastrzebski and Jan Sedzik -- In meso approaches to membrane protein crystallization / Valentin I. Gordeliy and Ekaterina S. Moiseeva -- Amyloid, the amyloid [beta]-peptide, and Alzheimer's disease : structural considerations / Lars O. Tjernberg -- Recent advances in structural basis for molecular mimicry in inflammatory autoimmune demyelinating polyneuropathy / Xin Yang -- Fresh water pearls of wisdom on protein crystallization / Jan Sedzik.

This volume, dealing with Nucleation, Aggregation and Crystallization, consists of a compilation of lectures offered at the international course held at Karolinska Institute and at the scientific meetings of the MARIE Network. The word "nucleation", derived from "nuclear family", refers to the concept of the progenitor, or the mother and the father of any family. Only in the last few centuries have physicists "borrowed" the word, and more recently, biologists for Theodor Schwann's cell theory. Most recently, the term has come into use in atomic theory, spectroscopy, and radioactivity, as well as in the fields of atomic bombs, fission, and fusion. Nucleation as a physicochemical process is followed by two poorly understood phenomena - aggregation and crystallization - which underlie disorders like Alzheimer's and "mad-cow" disease (aggregation of amyloid plaque), cardiovascular diseases (deposition in coronary vessels of cholesterol and lipids), and the appearance of crystals under physiological conditions (gout, silicoses, and liver or kidney stones). Written by leading scientists in the field, including one Nobel Laureate, this book provides a unique perspective between the physical and chemical sciences on the one hand, and the biological and medical sciences on the other, and should be of considerable value to scientists, physicians, students, and the interested lay public.

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