Metal ions and neurodegenerative disorders / editor, Paolo Zatta.

Includes bibliographical references and index.

Print version record.

Numerous studies have established a clear connection between neuronal oxidative stress and several neurodegenerative diseases, with consequential damages to lipids, proteins, nucleic acids, etc. In addition, several modifications indicative of oxidative stress have been described in association with neurons, neurofibrillary tangles and senile plaques in Alzheimer's disease, including advanced glycation end products and free carbonyl oxidation. Oxidative damage and antioxidant responses are now well characterized, but sources of damaging free radicals are yet to be fully understood. Evidences of alteration in metal ions metabolism have been reported in various diseases like Alzheimer's, Wilson, Menkes, Prion, Pick, Huntington disease, epilepsy and other pathological events. Thus, metal ions play a pivotal role in neurodegenerative phenomena. Chelation therapy is still in the early days of its development, but research in this area could lead to new products that could revolutionize treatment. Two international conferences on "Metals and the Brain: From Neurochemistry to Neurodegeneration" (Padova, Italy, 2000 and Fez, Morocco, 2002) were recently held to discuss the role of metal ions in neurophysiopathology. A third will be held in 2005 in Johannesburg, South Africa. This book follows the same train of thought as those conferences, in order to highlight the unquestionable importance of metal ions in the research on the neurophysiopathology of neurodegenerative diseases. The excellent reputation of the scientists who have contributed to this project ensures the quality of the chapters presented here, and hopefully this will help spur new research initiatives in the field, which is still in its infancy.

Preface -- List of contributors -- ch. 1. Metal-catalyzed redox activity in neurodegenerative disease / Marta A. Taddeo [and others] -- ch. 2. Metals distribution and regionalization in the brain / Margherita Speziali, Edoardo Orvini -- ch. 3. The Olfactory pathway as a route of entry of metals into the brain / Hans Tjälve, Jonas Tallkvist -- ch. 4. Aluminum in neurological disorders and systemic chelation therapy / Theo P. Kruck, Walter J. Lukiw -- ch. 5. Alumium and central nervous system morphology in hemodialysis / Erich Reusche -- ch. 6. Zinc, brain, and aging / Eugenio Mocchegiani [and others] -- ch. 7. Transition metals, oxidation, lipoproteins, and amyloid-[symbol]: major players in Alzheimer's disease / Anatol Kontush -- ch. 8. Molecular basis of copper transport: cellular and physiological functions of Menkes and Wilson disease proteins (ATP7A and ATP7B) / David R. Kramer, Roxana M. Llanos, Julian F.B. Mercer -- ch. 9. Importance of copper and zinc in Alzheimer's disease and the biology of amyloid-[symbol] protein and amyloid-[symbol] protein precursor / Avi L. Friedlich [and others] -- ch. 10. Copper-zinc superoxide dismutase and familial amyotrophic lateral sclerosis / Moon B. Yim, P. Boon Chock, Earl R. Stadtman -- ch. 11. Copper and Prion Disease / Judyth Sasson, David R. Brown -- ch. 12. Metallothioneins in neurodegeneration / Michael Aschner [and others] -- ch. 13. Iron and neurodegeneration / Stacey L. Grab, James R. Connor -- ch. 14. Iron, neuromelanin, and [symbol]-synuclein in neuropathogenesis of Parkinson's disease / Kay L. Double [and others] -- ch. 15. Iron and epilepsy / Wie-Yi Ong [and others] -- ch. 16. Role of iron metabolism in multiple sclerosis / Maritha J. Kotze [and others] -- ch. 17. Manganese toxicity: a critical reappraisal / Patrizia Vernole [and others] -- ch. 18. Cupric and mercuric ions affect the structure and functions of cell membranes / Mario Suwalsky [and others] -- ch. 19. Influence of lead exposure on brainstem functions / Ombretta Mameli, Marcello Alessandro Caria -- ch. 20. Neuroprotective effects of lithium / Sophie Ermidiou-Pollet, Serge Pollet -- ch. 21. Histopathological changes in brain of uremic patients on chronic hemodialysis / Pamela Zambenedetti [and others] -- ch. 22. Clinical neurotoxicity of metals and neurodegenerative disorders / Marcello Lotti -- Index.

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