NR coregulators and human diseases / Rakesh Kumar, Bert W. O'Malley.

Includes bibliographical references and index.

Nuclear receptor coregulators in human disease / Rainer B. Lanz, David M. Lonard, and Bert W. O'Malley -- P160 coactivators : critical mediators of transcriptional activation by nuclear receptors / Jeong Hoon Kim and Michael R. Stallcup -- Regulation of nuclear hormone receptor functions by ubiquitin-proteasome pathway / Ayesha Ismail, Heath Catoe, Sarath Dhananjayan, and Zafar Nawaz -- Coregulators as oncogenes and tumor suppressors / Rakesh Kumar and Anupama E. Gururaj -- A central role of SRC-3/AIB1 in tumorigenesis / Jun Yan, Sophia Y. Tsai, and Ming-Jer Tsai -- Thyroid hormone receptors, coregulators, and disease / Martin L. Privalsky -- Androgen receptor coactivators in prostate cancer / Nancy L. Weigel and Irina U. Agoulnik -- PGC-1 and metabolic control in skeletal and cardian muscle / Zolt Arany and Bruce M. Spiegelman -- Coregulators in metabolic and neurodegenerative diseases / Jérôme N. Feige, Hiroyasu Yamamoto, and Johan Auwerx -- Role of the RIP140 corepressor in metabolic regulation / Malcolm G. Parker, Mark Christian, Evangelos Kiskinis, Asha Seth, Donna Nichol, and Roger White -- Nuclear receptor corepressors and metabolism / Theresa Alenghat and Mitchell A. Lazar -- Coregulators in CNS functions and disease / O.C. Meijer and E.R. de Kloet -- Tissue repair and cancer control through PPARs and their coregulators / Liliane Michalik and Walter Wahli -- Coregulators and inflammation / Serena Ghisletti, Wendy Huang, and Christopher K. Glass -- Nuclear receptor coactivators in the cardiovascular system / Jianming Xu -- Coregulators as determinants of Selective Receptor Modulator (SRM) activity / Margaret C. Pace and Carolyn L. Smith -- Coregulators in toxicology / Joëgg, Malin Hedengran-Gaulds, Manuela Hase, Ingemar Pongratz and Jan-Åke Gustafsson -- Nuclear receptor coactivators co-ordiante metabolic response to hormonal and environmental stimuli / Ronald M. Evans, Michael Downes, Russell R. Nofsinger, Jun Sonoda and Ruth T. Yu -- Nuclear receptor cofactor interactions as targets for new drug discover / Linda L. Grasfeder and Donald P. McDonnell.

Print version record.

This book serves as a treasure for all those who have an interest in nuclear receptor coregulators and human diseases. Written by experts in the field, each chapter provides comprehensive, up-to-date information on the physiologic and pathologic roles of coregulators in specific organ systems, giving biomedical students; basic and clinical researchers; and educators in diverse sub-specialties a thorough summary of the overall subject. Readers will be able to understand the important current information and views on specific coactivators and corepressors and their roles in the pathogenesis of human diseases in areas outside their own expertise or experience. A special emphasis is placed on the "classic" papers as well as perspectives on future directions for the field.

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