Principles of tissue engineering / edited by Robert Lanza, Robert Langer, Joseph Vacanti.

Includes bibliographical references and index.

Print version record.

Front cover; PRINCIPLES OF TISSUE ENGINEERING; Copyright page; CONTENTS IN BRIEF; Table of contents; CONTRIBUTORS; FOREWORD; PREFACE; PREFACE TO THE SECOND EDITION; PREFACE TO THE FIRST EDITION; Introduction to Tissue Engineering; Chapter One: The History and Scope of Tissue Engineering; I. INTRODUCTION; II. SCIENTIFIC CHALLENGES; III. CELLS; IV. MATERIALS; V. GENERAL SCIENTIFIC ISSUES; VI. SOCIAL CHALLENGES; VII. REFERENCES; Chapter Two: The Challenge of Imitating Nature; I. INTRODUCTION; II. CELL TECHNOLOGY; III. CONSTRUCT TECHNOLOGY; IV. INTEGRATION INTO THE LIVING SYSTEM

v. CONCLUDING DISCUSSIONVI. ACKNOWLEDGMENTS; VII. REFERENCES; Chapter Three: Moving into the Clinic; I. INTRODUCTION; II. HISTORY OF CLINICAL TISSUE ENGINEERING; III. STRATEGIES TO ADVANCE TOWARD THE CLINIC; IV. BRINGING TECHNOLOGY PLATFORMS TO THE CLINICAL SETTING; V. TRANSITION TO CLINICAL TESTING; VI. ESTABLISHING A REGULATORY PATHWAY; VII. CONCLUSIONS; VIII. ACKNOWLEDGMENTS; IX. REFERENCES; Chapter Four: Future Perspectives; I. CLINICAL NEED; II. CURRENT STATE OF THE FIELD; III. CURRENT CHALLENGES; IV. FUTURE DIRECTIONS; V. FUTURE CHALLENGES; VI. REFERENCES

Part One: The Basis of Growth and DifferentiationChapter Five: Molecular Biology of the Cell; I. INTRODUCTION; II. THE CELL NUCLEUS; III. THE CYTOPLASM; IV. GROWTH AND DEATH; V. CYTOSKELETON; VI. CELL ADHESION MOLECULES; VII. EXTRACELLULAR MATRIX; VIII. CULTURE MEDIA; IX. CELLS IN TISSUES; X. FURTHER READING; Chapter Six: Organization of Cells into Higher-Ordered Structures; I. INTRODUCTION; II. MOLECULAR MECHANISMS OF THE EMT; III. THE EMT TRANSCRIPTIONAL PROGRAM; IV. MOLECULAR CONTROL OF THE EMT; V. CONCLUSION; VI. REFERENCES; Chapter Seven: The Dynamics of Cell-ECM Interactions

I. INTRODUCTIONII. CELL-ECM INTERACTIONS; III. SIGNAL TRANSDUCTION EVENTS DURING CELL-ECM INTERACTIONS; IV. RELEVANCE FOR TISSUE ENGINEERING; V. REFERENCES; Chapter Eight: Matrix Molecules and Their Ligands; I. INTRODUCTION; II. COLLAGENS -- MAJOR CONSTITUENTS OF ECM; III. ELASTIC FIBERS AND MICROFIBRILS; IV. OTHER MULTIFUNCTIONAL PROTEINS IN ECM; V. PROTEOGLYCANS -- MULTIFUNCTIONAL MOLECULES IN THE EXTRACELLULAR MATRIX AND ON CELL SURFACES; VI. CONCLUSION; VII. REFERENCES; Chapter Nine: Morphogenesis and Tissue Engineering; I. INTRODUCTION; II. BONE MORPHOGENETIC PROTEINS (BMPs)

III. CARTILAGE-DERIVED MORPHOGENETIC PROTEINS (CDMPs)IV. PLEIOTROPY AND THRESHOLDS; V. BMPs BIND TO EXTRACELLULAR MATRIX; VI. BMP RECEPTORS; VII. RESPONDING STEM CELLS; VIII. MORPHOGENS AND GENE THERAPY; IX. BIOMIMETIC BIOMATERIALS; X. TISSUE ENGINEERING OF BONES AND JOINTS; XI. FUTURE CHALLENGES; XII. ACKNOWLEDGMENTS; XIII. REFERENCES; Chapter Ten: Gene Expression, Cell Determination, and Differentiation; I. INTRODUCTION; II. DETERMINATION AND DIFFERENTIATION; III. MyoD AND THE bHLH FAMILY OF DEVELOPMENTAL REGULATORY FACTORS; IV. MEFs -- COREGULATORS OF DEVELOPMENT; V. PAX IN DEVELOPMENT

First published in 1997, Principles of Tissue Engineering is the widely recognized definitive resource in the field. The third edition provides a much needed update of the rapid progress that has been achieved in the field, combining the prerequisites for a general understanding of tissue growth and development, the tools and theoretical information needed to design tissues and organs, as well as a presentation by the world's experts of what is currently known about each specific organ system. This edition includes greatly expanded focus on stem cells, including adult and embryonic.

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