Immunoglobulin genes / edited by T. Honjo, F.W. Alt.

Contributor(s):

Material type: Text

text

Media type:

computer

Carrier type:

online resource

ISBN:

9780120536405
0120536404
9780080534510
0080534511

Subject(s): Genre/Form:

Electronic books.

Additional physical formats: Print version:: Immunoglobulin genes.DDC classification:

596/.0293 22

LOC classification:

QR186.7 .I43 1995eb

NLM classification:

QW 601

Other classification:

44.45

Online resources:

Click here to access online

Contents:

B Cells: Human B-Cell Differentiation. Murine B-Cell Differentiation. Somatic Mutation and B-Cell Maturation. Development of B-Cell Subsets. Regulation of B-Cell Differentiation By Stroma Cells. Antigen Receptors. Organization and Rearrangement of Immunoglobulin Genes: Immunoglobulin Heavy Chain Loci in Mouse and Men. The Human Immunoglobulin Genes. Organization of Lambda Chain Genes. VDJ Recombination. Regulation of Class Switch Recombination of the Immunoglobulin Heavy Chain Genes. Organization and Expression of Chicken and Sheep Ig Genes. Immunoglobulin Heavy Chain Genes of Rabbit. The Structure and Organization of Immunoglobulin Genes in Lower Vertebrates. Immunoglobulin Gene Expression: Ig Gene Expression and Regulation in Ig Transgenic Mice. B-Lymphocyte Tolerance in the Mouse. Auto Antibodies. Regulation of Ig H and L Chain Gene Transcription. Subject Index.

Action note:

digitized 2010 HathiTrust Digital Library committed to preserve

Summary: The immunoglobulin gene complex is responsible for generating an extraordinarily wide range of antibodies, each possessing a unique antigen specificity. The Second Edition of Immunoglobulin Genes brings the reader up to date with the rapid progress in our understanding of this system. Firmly established as the definitive book on the topic, it provides a fully comprehensive account of the organization, function, rearrangement and expression of these and related genes. Since the publication of the first edition, the work has been extensively revised and updated to cover new research data on human immunoglobulin genes as well as mammalian and lower vertebrate systems. New chapters include "Somatic mutation and B cell Maturation", "Antigen receptors" and "B lymphocyte tolerance in the mouse." For the immunologist, there are detailed descriptions of the molecular mechanisms which generate this diverse range of antibodies and the tight regulation of the genes encoding them. Molecular biologists will find discussions of important phenomena including gene rearrangement, differential splicing and deletion in the context of immunoglobulin genes. The excitement of research on immunoglobulin genes is conveyed by the range and complexity of issues discussed here; the book contains invaluable information for clinicians and research scientists with an interest in the immune response. * Conveys the excitement of research on immunoglobulin genes by the range and complexity of issues * Contains invaluable information for clinicians and research scientists with an interest in the immune response * For the Immunologist * Detailed descriptions of the molecular mechanisms generating this diverse range of antibodies and the regulation of genes encoding them * For the Molecular Biologist * Discusses important phenomena including gene rearrangement, differential splicing, and deletion in the context of immunoglobulin genes.

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The immunoglobulin gene complex is responsible for generating an extraordinarily wide range of antibodies, each possessing a unique antigen specificity. The Second Edition of Immunoglobulin Genes brings the reader up to date with the rapid progress in our understanding of this system. Firmly established as the definitive book on the topic, it provides a fully comprehensive account of the organization, function, rearrangement and expression of these and related genes. Since the publication of the first edition, the work has been extensively revised and updated to cover new research data on human immunoglobulin genes as well as mammalian and lower vertebrate systems. New chapters include "Somatic mutation and B cell Maturation", "Antigen receptors" and "B lymphocyte tolerance in the mouse." For the immunologist, there are detailed descriptions of the molecular mechanisms which generate this diverse range of antibodies and the tight regulation of the genes encoding them. Molecular biologists will find discussions of important phenomena including gene rearrangement, differential splicing and deletion in the context of immunoglobulin genes. The excitement of research on immunoglobulin genes is conveyed by the range and complexity of issues discussed here; the book contains invaluable information for clinicians and research scientists with an interest in the immune response. * Conveys the excitement of research on immunoglobulin genes by the range and complexity of issues * Contains invaluable information for clinicians and research scientists with an interest in the immune response * For the Immunologist * Detailed descriptions of the molecular mechanisms generating this diverse range of antibodies and the regulation of genes encoding them * For the Molecular Biologist * Discusses important phenomena including gene rearrangement, differential splicing, and deletion in the context of immunoglobulin genes.

Includes bibliographical references and index.

Print version record.

Use copy Restrictions unspecified star MiAaHDL

Electronic reproduction. [Place of publication not identified] : HathiTrust Digital Library, 2010. MiAaHDL

Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. MiAaHDL