Neurodegeneration and neuroprotection in Parkinson's disease / edited by C.W. Olanow, Peter Jenner, Moussa Youdim.

Includes bibliographical references and index.

Oxidative stress, brain iron and neurodegeneration : basic principles / John M.C. Gutteridge and Barry Halliwell -- Pathological evidence for oxidative stress in Parkinson's disease and related degenerative disorders / P. Jenner and C.W. Olanow -- Treatment of Parkinson's disease with deprenyl (selegiline) and other monoamine oxidase inhibitors / Karl Kieburtz and Ira Shoulson -- Iron and neurodegeneration : prospects for neuroprotection / C.W. Olanow and M.B.H. Youdim -- Nitrone radical traps protect in experimental neurodegenerative diseases / Robert A. Floyd and John M. Carney -- Therapeutic effects of nitric oxide synthase inhibition in neuronal injury / M. Flint Beal -- Mitochondrial dysfunction in neurodegeneration : prospects for neuroprotection / A.H.V. Schapira -- Bioenergetics and excitotoxicity : the weak excitotoxic hypothesis / James G. Greene and J. Timothy Greenamyre -- Calcium ions in necrotic and apoptotic cell death / Pierluigi Nicotera and Sten Orrenius -- Neurotrophic factors : towards a restorative therapy of Parkinson's disease / C. Anthony Altar, Stanley J. Wiegand, Ronald M. Lindsay and Jesse M. Cedarbaum -- Immune-mediated cell death and neuroprotection in neurodegenerative diseases / Stanley H. Appel, R. Glenn Smith and Wei Dong Le -- Reduction of neuronal apoptosis by small molecules : promise for new approaches to neurological therapy / William G. Tatton, William Y.H. Ju, J. Wadia and Nadine A. Tatton.

Neuroscience Perspectives provides multidisciplinary reviews of topics in one of the most divers and rapidly advancing fields in the life sciences. Whether you are a new recruit to neuroscience, or an established expert, look to this series for 'one-stop' sources of the historical, physiological, pharmacological, biochemical, molecular biological, and therapeutic aspects of chosen research areas.

Oxidant Stress: -- J.M.C. Gutteridge and B. Halliwell, Oxidative Stress, Brain Iron, and Neurodegeneration: Basic Principles. -- P. Jenner and C.W. Olanow, Pathological Evidence for Oxidative Stress in Parkinson's Disease and Related Degenerative Disorders. -- K. Kieburtz and I. Shoulson, Treatment of Parkinson's Disease with Deprenyl (Selegiline) and Other Mondamine Oxidase Inhibitors. -- C.W. Olanow and M.B.H. Youdim, Iron and Nuerodegeneration: Prospects for Neuroprotection. -- R.A. Floyd and J.M. Carney, Nitrone Radical traps (NRTs) Protect in Experimental Neurodegenerative Diseases. -- M. Flint Beal, Therapeutic Effects of NOS Inhibition in Neuronal Injury. Mitochodrial Toxicity: -- A.H.V Schapira, Mitochondrial Dysfunction in Neurodegeneration: Prospects for Neuroprotection. -- Excitatory Neurotoxicity: -- J.G. Greene and J.T. Greenamyre, Bioenergetics and Exitotoxicity: The Weak Excitotoxic Hypothesis. -- Calcium Exitatory Toxicity: -- P. Nicotera and S. Orrenius, Calcium Ions in Necrotic and Apoptotic Cell Death. Trophic Factors: -- C.A. Altar, S.J. Wiegand, R.M. Lindsay, and J.M. Cedarbaum, Neurotrophic Factors: Towards a Restorative Therapy of Parkinson's Disease. -- Immune Mechanisms: -- S.H. Appel, R.G. Smith, and W.D. Le, Immuno-Mediated Cell Death and Neuroprotection in Neurodegenerative Diseases. -- Apoptosis: -- W.G. Tatton, M.Y.H. Ju, J. Wadia, and N.A. Tatton, Reduction of Neuronal Apoptosis by Small Molecules: Promise for New Approaches to Neurological Therapy. Subject Index.

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