Free radicals and diseases : gene expression, cellular metabolism and pathophysiology / edited by Tilman Grune.

Includes bibliographical references and index.

Title page; Preface; Contents; DNA Lesions as Biomarkers of Inflammation and Oxidative Stress: A Preliminary Evaluation; Lipid Peroxidation Measurements -- Methodological Approaches and Clinical Importance; Role of Oxidative Stress in Aging of the Yeast Saccharomyces cerevisiae; mtNOS: Regulation by Mitochondrial Membrane Potential; Mutliplicity of Mitochondrial Functioning; ROS-Induced Oscillations of Mitochondrial Transmembrane Potential in Cultured Rat Astocytes; The Effects of Nitric Oxide and Peroxynitrite on MnSOD (E. coli).

This publication contains an extensive overview of free radicals and diseases, including both basic science approaches and clinical applications. The research of the last decades has contributed substantially to the understanding role and function of these metabolites. It is the aim of the editors to include a large variety of biological models ranging from yeast over mitochondria, isolated cells and cell culture models to animals and humans. The topics discussed focus on the function and integrity of mitochondria under oxidative conditions, the role of protein oxidation and proteolysis in the.

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