Cellular signaling and phosphoproteomics / edited by: Aleksei Anatoliyovych Stepanenko.

Cover; Half Title Page; Title Page; Copyright Page; Declaration; About the Editor; Table of Contents; List of Contributors; List of Abbreviations; Preface; Chapter 1 Lighting Up T Lymphocyte Signaling with Quantitative Phosphoproteomics; Abstract; Introduction; Phosphoproteomics Workflows; Tcr Signaling by Global Phosphoproteomics; Other Signaling Processes in T Lymphocytes; Conclusion; Perspectives; Acknowledgments; Footnotes; References; Chapter 2 Advances in Mass Spectrometry Based Strategies To Study Receptor Tyrosine Kinases; Introduction; Mass Spectrometry-Based Phosphoproteomics

Mass Spectrometry Unveils New RTK BiologyFuture Perspectives; Concluding Remarks; References; Chapter 3 Understanding Cell Signaling In Cancer Stem Cells for Targeted Therapy -- Can Phosphoproteomics Help To Reveal The Secrets?; Abstract; Background; Cancer Stem Cells and Tumor Heterogeneity; Deciphering The Phosphoproteome of CSC For The Development of Anti-CSC Therapies; Phosphoproteome Analysis of Cancer and Cancer Stem Cells; HPLC-MS/MS Workflow For Phosphoproteomics; Challenges of Analyzing The Phosphoproteome; Quantification of Changes In Phosphoproteome Regulation

Phosphoproteomic Applications For The Analysis of Cancer CellsCSC -- An Intricate Challenge For Proteomic and Phosphoproteomic Profiling; Conclusions; Acknowledgements; References; Chapter 4 Phosphoproteome Discovery In Human Biological Fluids; Abstract; Introduction; Bioanalytical Strategies; Applications To Biofluid Phosphoproteome Characterization; Concluding Remarks; Acknowledgments; References; Chapter 5 Role of Protein Phosphorylation In The Regulation of Cell Cycle and DNA-Related Processes In Bacteria; Abstract; Introduction

Identification of Phospho-Proteins Involved In DNA-Related Processes In BacteriaBiological Role of Phospho-Proteins In Coordinating DNA- Metabolism With Transition State And Cellular Development In B. Subtilis; Conclusions; Author Contributions; Acknowledgments; References; Chapter 6 Mass Spectrometry Offers Insight Into The Role of SER/THR/TYR Phosphorylation in The Mycobacteria; Abstract; Introduction; Comparative Phosphoproteomic Analysis of Mycobacteria; Current State of Phosphoproteomics; Recommendations For Future Research; Author Contributions; Acknowledgments; References

Chapter 7 Computational Phosphoproteomics: From Identification To LocalizationAbstract; Introduction; Benchmarking Studies Highlight Inconsistencies In Phosphopeptide Informatics; Identification of Phosphopeptides: Challenges And Issues; Activation Methods That Improve Phosphorylation Analyses; More Advanced Informatic Approaches To Improve Identification; Site Localization; Site Localization Algorithms; Probability-Based Localizers; SED Scores; The Status Of The False Localization Rate; Isomers And The Problems They Pose; Computational Phosphoproteomics In Practice

Data Standards Supporting Phosphoproteomics

Includes bibliographical references and index.

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