Myelodysplastic syndromes : from pathogenesis to diagnosis and therapy / Hamid Sayar, editor.

Includes bibliographical references and index.

MYELODYSPLASTIC SYNDROMES ; MYELODYSPLASTIC SYNDROMES ; Contents ; Preface ; An Introduction to Myelodysplastic Syndromes: Presentation, Diagnosis, Classification, and Prognostication ; Abstract ; Introduction ; Etiology ; Pathobiology ; Cytogenetic, Genetic, and Epigenetic Alterations ; Cytogenetic Abnormalities ; Genetic Abnormalities ; Epigenetic Abnormalities ; Role of Immune System ; Bone Marrow Microenvironment ; Deregulated Apoptosis (Programmed Cell Death) ; Clinical Presentation ; Diagnosis ; Bone Marrow Aspirate.

Practical Technique to Assure Adequate Bone Marrow Particle Collection Bone Marrow Biopsy ; Touch Imprint and Clot Section ; Flow Cytometry ; Cytogenetics ; Atypical Forms of MDS ; MDS with Myelofibrosis ; Hypoplastic MDS ; Myelodysplastic/Myeloproliferative Neoplasms (MDS/MPN) ; Therapy Related MDS (t-MDS) ; 5q- Syndrome ; Classification ; Prognostication ; International Prognostic Scoring System (IPSS) ; WHO Prognostic Scoring System (WPSS) ; MD Anderson Cancer Center (MDACC) Model ; Revised IPSS (IPSS-R) ; Other Prognostic Factors ; Cytogenetics ; Bone Marrow Fibrosis ; Hypoplastic MDS.

Therapy-Related MDS (t-MDS) 5q- Syndrome ; Neutropania ; Thrombocytopenia ; References ; Diagnostic Approach to Myelodysplastic Syndromes ; Abstract ; Introduction ; Diagnostic Approach ; Morphologic Features ; Immunophenotyping by Flow Cytometry ; Cytogenetic and Genetic Features ; Classification of Myelodisplastic Syndromes ; Refractory Cytopenia with Unilineage Dysplasia (RCUD) ; Refractory Anemia with Ring Sideroblasts (RARS) ; Refractory Cytopenia with Multilineage Dysplasia (RCMD) ; Refractory Anemia with Excess of Blasts (RAEB) ; Myelodysplastic Syndrome with Isolated del(5q).

Myelodysplastic Syndrome, Unclassifiable (MDS-U) Myelodysplastic Syndromes with Unique Morphological Features ; MDS with Fibrosis (MDS-F) ; Hypoplastic MDS (h-MDS) ; Erythroid-Predominant MDS (MDS-E) ; Conclusion ; References ; Cytogenetic Features of Myelodysplastic Syndromes ; Abstract ; Introduction ; Cytogenetic Findings ; Cytogenetic Alterations and their Molecular Counterparts ; Y Chromosome Loss ; Rearrangements (3q) ; Deletion (5q) ; Rearrangements of 5q33 ; Partial or Total Loss of Chromosome 7: -7/del(7q) ; Trisomy 8 ; Deletion (17p) ; Deletion (20q) ; Complex Karyotype.

Risk Stratification of Cytogenetic Findings in MDS Conclusion ; Acknowledgments ; References ; Molecular Genetic Abnormalitiesin Myelodysplastic Syndromes ; Abstract ; Introduction ; Mutations in Epigenetic Regulators in MDS ; Mutations of the DNMT3A Gene ; Mutations of the TET2 Gene ; Mutations of the IDH1 and IDH2 Genes ; Mutations of the EZH2 Gene ; Mutations of the UTX Gene ; Mutations of the ASXL1 Gene ; Mutations of the c-CBL Gene ; RUNX1 Mutations ; RAS Mutations in MDS ; TP53 Mutations ; Mutations in RNA Splicing Machinery; Mutations in Other Genes in MDS Patients.

Annotation In spite of tremendous advances in the field, the current understanding of pathogenesis of myelodysplastic syndromes (MDS) remains limited. Furthermore, the correct diagnosis and effective therapy of this heterogeneous group of clonal haematological disorders represent a common challenge in daily practice of haematology. This book provides a thorough, up-to-date, and comprehensive review of different aspects of MDS. Chapters are written by selected investigators and clinicians with specific expertise and track record of research in the field. Of particular interest, the clinical chapters provide a practical approach to the treatment of patients with different manifestations of the disease. This book would be a useful asset to researchers in the field as well as haematologists in practice. Other health care members such as haematology fellows in training, residents, medical students and nurses will also find this book helpful for better understanding of the disease and clinical management of patients with MDS.

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