Intrinsically disordered proteins (IDPs) : structural characterization, therapeutic applications and future directions / Violet Weber, editor.

Includes bibliographical references and index.

Description based on print version record.

INTRINSICALLY DISORDERED PROTEINS (IDPS): STRUCTURAL CHARACTERIZATION, THERAPEUTIC APPLICATIONS AND FUTURE DIRECTIONS; INTRINSICALLY DISORDERED PROTEINS (IDPS): STRUCTURAL CHARACTERIZATION, THERAPEUTIC APPLICATIONS AND FUTURE DIRECTIONS; Library of Congress Cataloging-in-Publication Data; CONTENTS; PREFACE; Chapter 1: INTRINSIC DISORDER INDNA-BINDING PROTEINS; ABSTRACT; INTRODUCTION; 1. CHROMATIN ARCHITECTURAL PROTEINS; 2. TRANSCRIPTION FACTORS; 3. INTRINSICALLY DISORDERED PROTEINS IN DNA METABOLISM; CONCLUSION; REFERENCES

Chapter 2: STRUCTURAL ANALYSIS OF INTRINSICALLY DISORDERED PROTEINS: COMPUTER ATOMISTIC SIMULATIONAbstract; 1. Introduction; 2. The Tau Protein; 3. Initial Configuration and Dynamical Evolution; 4. Secondary Structures; 5. Tertiary Structures; 6. Fit of Experimental SAXS Data; 7. Transient Structures; 8. Conclusion; Acknowledgment; References; Chapter 3: BIOPHYSICAL CHARACTERIZATION OF INTRINSICALLY DISORDERED PROTEINS AND THEIR COMPLEXES: CHALLENGES AND CONTRADICTIONS; ABSTRACT; INTRODUCTION; DO IDPS FOLD UPON BINDING TO THE CELL MEMBRANE?; DO IDPS DIMERIZE?; CONCLUSION; REFERENCES; INDEX

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