Membrane organization and lipid rafts in the cell and artificial membranes / editor, Angel Catalá (Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas, (INIFTA-CCT La Plata-CONICET), Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Argentina).

Includes bibliographical references and index.

Print version record and CIP data provided by publisher.

MEMBRANE ORGANIZATION AND LIPID RAFTS IN THE CELL AND ARTIFICIAL MEMBRANES ; MEMBRANE ORGANIZATION AND LIPID RAFTS IN THE CELL AND ARTIFICIAL MEMBRANES ; Library of Congress Cataloging-in-Publication Data; CONTENTS ; PREFACE ; Chapter 1 FLUID -MOSAIC CELL MEMBRANE STRUCTURE: FROM CELLULAR CONTROL AND DOMAINS TO EXTRACELLULAR VESSICLES ; ABSTRACT ; ABBREVIATIONS ; INTRODUCTION ; CELL MEMBRANE PROPERTIES ; FLUID-MOSAIC MODEL OF CELL MEMBRANE STRUCTURE ; Membrane Cytoskeletal and Matrix Interactions ; Cell Membrane Protein and Lipid Interactions

Membrane Mobility Restrictions and Hierarchical Cell Membrane OrganizationMembrane Fusion and Membrane Vesicles ; Membrane Protusions from Normal and Tumor Cells ; Extracellular Vesicles and Exosomes ; FINAL COMMENT ; CONFLICT OF INTEREST ; ACKNOWLEDGMENTS ; REFERENCES ; Chapter2LIPIDRAFTSINBINARYLIPID/CHOLESTEROLBILAYERS; Abstract; 1. THERAFTCONCEPT; 2. DOMAINFORMATIONINMODELLIPIDMEMBRANES; 2.1. PhysicalPropertiesofLipids; 2.2. PhaseSeparationinMixed-ComponentModelLipidMembranes; 2.3. ModulatedPhasesandMicroemulsions; 3.X-RAYANDNEUTRONSCATTERINGEXPERIMENTSOFBINARYLIPID/CHOLESTEROLMEMBRANES

3.1. StructureDeterminationbyDiffraction3.2. IdentificationofCholesterolPlaquesUsingX-RayDiffraction; 3.3. IdentificationofRaftsUsingNeutronDiffraction; 3.4. DynamicsofBinaryMixtures; 4. DRUGINTERACTIONSWITHMEMBRANEPATCHES; 5. ADDITIONALFRONTIERSINRAFTBIOPHYSICS; 6. CONCLUSION; Acknowledgments; References; Chapter 3 MEMBRANE ASSEMBLY AND LIPID RAFTS IN THE CELL AND ARTIFICIAL MEMBRANES: EFFECT OF LIPID PEROXIDATION ; ABSTRACT ; FLUID MOSAIC MODEL OF BIOLOGICAL MEMBRANE STRUCTURE ; LIPID RAFTS; BIOLOGICAL MEMBRANES IN CELLS ARE DIFFERENT FROM ARTIFICIAL MEMBRANES

THE DAMAGING EFFECTS OF LIPID PEROXIDATION ON MEMBRANE STRUCTURE AND FUNCTION THE LIPID PEROXIDATION PROCESS PRODUCES OXIDIZED PHOSPHOLIPIDS THAT ACQUIRE NEW BIOLOGICAL ACTIVITIES NOT CHARACTERISTIC OF THEIR UNOXIDIZED PRECURSORS ; THE CHANGES INDUCED BY LIPID PEROXIDATION IN MEMBRANE STRUCTURE AND DYNAMICS, BOTH AT THE LIPID AND PROTEIN LEVEL ; ACKNOWLEDGMENTS; REFERENCES; Chapter 4 DRUGS, DELIVERY SYSTEMS AND MEMBRANE ORGANIZATION IN MODEL AND CELL MEMBRANES ; ABSTRACT ; ABBREVIATIONS ; 1. INTRODUCTION ; 2. SPHINGOLIPIDS: METABOLISM, MEMBRANE ORGANIZATION AND CELL FUNCTION

2.1. Sphingoid Bases2.2. Ceramide ; 2.3. Sphingomyelin; 2.4. GSLs ; 3. MEMBRANE ORGANIZATION AND CHEMOTHERAPEUTIC AGENTS ; 3.1. Modulation of Membrane Biophysical Properties by Chemotherapeutics ; 3.2. Membrane Properties-Dependent Antitumoral Agents ; 4. DELIVERY SYSTEMS ; 4.1. Dendrimers ; 4.2. Particulate Delivery Systems ; 4.2.1. Liposomes; 4.2.1.1. Ceramide-Containing Liposomes as Delivery Systems in Cancer Treatment ; 4.2.2. Other Particulate Delivery Systems ; CONCLUSION; REFERENCES

"This book presents an overview of membrane organization and lipid rafts in the cell and artificial membranes. The topics analyzed in this book cover a broad spectrum of functions played by lipid rafts in membrane organization within the cell and artificial membranes, and presents new information in this area of research. The topics analyzed include: fluid-mosaic cell membrane structure from cellular control and domains to extracellular vesicles; lipid rafts in binary lipid/cholesterol membranes; membrane assembly and lipid rafts in the cell and artificial membranes; the effect of lipid peroxidation; drugs, delivery systems and membrane organization in model and cell membranes; role of sphingomyelin on membrane domain formation and its influence in protein interaction focusing on the nanometer scale; lipid rafts and cell adhesion; mutual modulators of cell signaling; and finally, roles of glycosphingolipids in the regulation of the membrane organization and cell signaling in lipid rafts."-- Provided by publisher.

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