Polyphosphazenes for medical applications / Ian Teasdale and Oliver Brüggemann.

Includes bibliographical references and index.

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Preface; 1 Synthetic Procedures; 1.1 Poly(dichloro)phosphazene; 1.2 Macromolecular Substitution; 1.3 Ring-opening Polymerisation; 1.4 Chain Growth Polycondensation; 1.5 Macromolecular Architecture; 1.5.1 P-N Backbone Branching; 1.5.2 Grafting; 1.5.3 Block Copolymers; 1.5.4 Self-assembly; 1.6 Conclusion; References; 2 Degradable Poly(organo) phosphazenes; 2.1 Bioerodible Polymers for Biomedicine; 2.1.1 Bioerodible Solid Biomaterials and Polymer Matrices; 2.1.2 Water-soluble, Degradable Polymers; 2.2 Poly(organo)phosphazene Degradation.

2.2.1 Side-group Influence on Degradation Kinetics2.2.2 Amino Acid Ester-derived Polyphosphazenes; 2.2.3 The Effect of pH; 2.3 Degradable Molecular-level Hybrids; 2.4 Blends of Poly(organo)phosphazenes; 2.5 Bulk versus Surface Erosion; 2.6 Degradation Product Cytotoxicity; 2.7 Conclusion; References; 3 Nanomedicine; 3.1 Polyphosphazenes in Immunology; 3.1.1 Vaccine Adjuvants and Delivery Systems; 3.1.2 Polyphosphazene Electrolytes as Immunological Adjuvants; 3.1.3 Structure Activity Relationships; 3.1.4 Safety Considerations; 3.1.5 Immunological Activity.

3.1.6 Polyelectrolyte Microsphere Formulations3.1.7 Alternative Delivery Routes; 3.2 Cationic Polyphosphazenes and their Polyplexes; 3.2.1 Gene Delivery; 3.2.2 Gene Silencing; 3.2.3 Charged Polyphosphazenes for Enteral Drug Delivery; 3.3 Controlled Release from Polyphosphazene Matrices; 3.3.1 Polyphosphazene-based Drug Depot Devices; 3.3.2 Covalently Bound Drug Depot Devices; 3.3.3 Cyclomatrix Polyphosphazenes as Drug Depots; 3.4 Micelles and Polymersomes; 3.5 Polymer Therapeutics; 3.5.1 Macromolecular Drug Carriers; 3.5.2 Polyphosphazene Drug Conjugates.

3.5.3 Polyphosphazene Carriers for Photodynamic Therapy3.5.4 Enteral Delivery; 3.6 Thermosensitive Poly(organo)phosphazenes; 3.6.1 Thermosensitive Polymers; 3.6.2 Thermosensitive Polyphosphazene Drug Carriers; 3.6.3 Injectable Hydrogels; 3.7 Conclusion; References; 4 Tissue Engineering; 4.1 Introduction to Tissue Engineering; 4.2 Architecture of Polyphosphazene Scaffolds for Tissue Engineering; 4.2.1 Formats; 4.2.1.1 Linear Polyphosphazenes; 4.2.1.2 Crosslinked Polyphosphazenes; 4.2.2 Properties; 4.3 Applications of Polyphosphazene Scaffolds in Tissue Engineering.

4.3.1 Bone Tissue Engineering4.3.2 Endothelial Tissue Engineering; 4.3.3 Neural Tissue Engineering; 4.4 Degradation of Polyphosphazenes Developed for Tissue Engineering; 4.5 Conclusion; References; 5 Opportunities and Challenges; 5.1 From Laboratory to Clinic; 5.2 Future Prospects; References; Abbreviations; Index.

Polyphosphazenes are a unique family of inorganic polymers with an unparalleled broad spectrum. of properties. Furthermore, these properties can be easily fine-tuned by organic side-group substituents to give poly(organo)phosphazenes with precisely desired characteristics making them valuable tools to prepare multifunctional, advanced materials for biomedical applications. Bioerodible poly(organo)phosphazenes are of particular interest and with suitable organic substituents their rate of degradation can be tailored to give materials ranging from highly biostable to rapidly hydrolysable, with p.

English.

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