Stress and developmental programming of health and disease : beyond phenomenology / Lubo Zhang, PH.D. and Lawrence D. Longo, M.D., editors.

Includes bibliographical references and index.

Description based on print version record and CIP data provided by publisher.

STRESS AND DEVELOPMENTAL PROGRAMMING OF HEALTH AND DISEASE: BEYOND PHENOMENOLOGY; STRESS AND DEVELOPMENTAL PROGRAMMING OF HEALTH AND DISEASE: BEYOND PHENOMENOLOGY; Library of Congress Cataloging-in-Publication Data; Contents; Preface; References; Acknowledgments; Chapter 1: Developmental Origins of Health and Disease: The Past and the Future; Abstract; Introduction; Historical Origins; Barriers to the Acceptance of the DOHaD Concept; DOHaD and the Global NCD Agenda; Conclusion; References; Chapter 2: Programming and the Barker Hypothesis; Abstract; Introduction.

Vulnerable Periods of Embryonic DevelopmentVulnerable Periods of Fetal Development; Maternal Undernutrition and Overnutrition; Maternal Nutrition, Birthweight and Later Disease; Glucocorticoids and Heart Development; Substance Abuse; Conclusion; References; Chapter 3: Stress and Programming of Metabolic Disease; Abstract; 1. The Impact of Poor Maternal Nutrition During the Periconceptional Period on the HPA Axis in Fetal and Postnatal Life; 2. The Key Regulators of Metabolic Health in Adult Life; 3. The Metabolic Consequences of Maternal Undernutrition during the Periconceptional Period.

4. The Impact of Restriction of Placental and Fetal Growth on the HPA Axis and Programing of Metabolic Diseases5. The Impact of Maternal Glucocorticoid Exposure on the HPA Axis and Programing of Metabolic Diseases; 6. The Epigenetic Programming of the HPA Axis; Conclusion; References; Chapter 4: The Stress of Chronic Hypoxia in Fetal Growth Restriction: Some Physiological Considerations; Abstract; Abbreviations; An Introduction to Fetal Growth Restriction; The Recognition of Fetal Growth Restriction; Fetal Growth Restriction in Laboratory Animals.

Cardiovascular Function with Fetal Growth RestrictionHypoxia-Mediated FGR and Neuropsychological Correlates; Hypoxia-Mediated FGR and the Placenta; Hypoxia-Mediated FGR and the Developmental Origins of Adult Health and Disease; Conclusion with Perspective; Acknowledgment; References; Chapter 5: Fetal Stress and Growth Restriction at High Altitude; Abstract; Abbreviations; High Altitude Long-Term Hypoxia and the Human Condition; The Colorado and Mountain States Studies; Studies from South America; The Relation of Birthweight to Gestational Age.

Translational Studies of Pregnancy at High AltitudeStudies of Prolonged Hypoxia in Rodents; Fetal Cardiovascular Responses to Long-Term Hypoxia; Studies in the Chick Embryo; Fetal Adaptive and Maladaptive Responses to Hypoxia; Fetal Coronary Vascular Responses; High Altitude, Long-Term Hypoxia in Sheep; Fetal Cerebrovascular Responses to Long-Term Hypoxia; Some Aspects of Cardiovascular Function in the Llama Fetus; Long-Term Hypoxia and the Fetal Hypothalamic-Pituitary-Adrenal Axis; Fetal Metabolic Responses to LTH; Hypoxia-Mediated FGR and Neuropsychological Correlates.

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