Handbook of proteolytic enzymes / edited by, Neil D. Rawlings, Guy Salvesen.

Previous edition: London: Elsevier Academic, 2004.

Includes bibliographical references and index.

Front Cover; Handbook of Proteolytic Enzymes; Copyright Page; Contents; Editor Biographies; Contributors; Preface; Introduction; Terminology; Organization of the Handbook; Special forms of information in the Handbook; Links to the MEROPS database; Molecular images; Alignments; Secondary structure; Description of substrate specificity; References; Aspartic Peptidases; 1 Introduction: Aspartic and Glutamic Peptidases and Their Clans; Clan AA; Family A1; Other Families in Clan AA; Clan AF; Clan AC; Clan AD; Clan AE; Other Families; Glutamic Peptidases; Asparagine Peptide Lyases.

Clans NA, NC and NE; Inteins; Autotransporters; References; 2 Catalytic Pathways of Aspartic Peptidases; Introduction; Enzymatic Mechanism of Aspartic Peptidases; Enzymatic Mechanism of Glutamic Peptidases; References; 3 Pepsin A; Databanks; Name and History; Activity and Specificity; Structural Chemistry; Pepsinogen; Preparation; Biological Aspects; Related Peptidases; Further Reading; References; 4 Pepsin B; Databanks; Name and History; Activity and Specificity; Structural Chemistry; Preparation; Biological Aspects; Further Reading; References; 5 Chymosin; Databanks; Name and History.

Activity and Specificity; Structural Chemistry; Preparation; Biological Aspects; Distinguishing Features; Related Proteinases; Further Reading; References; 6 Cathepsin E; Databanks; Name and History; Activity and Specificity; Structural Chemistry; Preparation; Biological Aspects; Tissue Distribution and Subcellular Localization; Regulation of Gene Expression; Processing, Maturation and Intracellular Trafficking Of Cathepsin E; Physiological Roles of Cathepsin E; Distinguishing Features; Further Reading; References; 7 Gastricsin; Databanks; Name and History; Activity and Specificity.

Structural Chemistry; Progastricsin; Preparation; Biological Aspects; References; 8 Cathepsin D; Databanks; Name and History; Activity and Specificity; Assay Methods; Specificity; Inhibition and Activation; Structural Chemistry; Three-dimensional Structure; Preparation; Biological Aspects; Gene and Expression Control; Knock-out Model; Organ Distribution and Cellular Localization; Apoptosis; Involvement in Cancer; Neurodegeneration; Other Biological Functions; Distinguishing Features; Related Peptidases; Acknowledgment; Further Reading; References; 9 Nothepsin; Databanks; Name and History.

Activity and Specificity; Structural Chemistry; Primary Structure Analysis; Distinguishing Features of This New Class of Aspartic Proteinases; Retrieval and Sequencing of Nothepsin Enzymes; Presence of a Nothepsin Enzyme in Non-Antarctic Fish; Nothepsin in Organisms Other Than Fish; Preparation; Biological Aspects; Expression Pattern of the Nothepsin in Fish and Lizard; Phylogenetic Analysis, Adaptive Evolution and Role of Nothepsin; Further Reading; References; 10 Napsin A; Databanks; Name and History; Activity and Specificity; Structural Chemistry; Preparation; Biological Aspects.

The third edition of the Handbook of Proteolytic Enzymes is a fully revised and updated major reference work in Elsevier's canon. For the first time the Handbook will be available as an online via Elsevier's ScienceDirect platform as well as a three-volume book. The online version will have the enhanced options including online multimedia, cross-referencing capabilities, integrated online delivery and closer integration with the online MEROPS database of peptidases and their inhibitors. This reference work is intended for university libraries, researchers and students, and will be of great.

eBooks on EBSCOhost EBSCO eBook Subscription Academic Collection - Worldwide