MARC details
| 000 -LEADER |
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| fixed length control field |
03174namaa2200613uu 4500 |
| 001 - CONTROL NUMBER |
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| control field |
oapen32342 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
oapen |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20231221095512.0 |
| 006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS--GENERAL INFORMATION |
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| fixed length control field |
m o d |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
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| fixed length control field |
cr|mn|---annan |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
191004s2011 xx |||||o ||| 0|eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
23332 |
| 024 7# - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
10.5772/23332 |
| Source of number or code |
doi |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
oapen |
| Transcribing agency |
oapen |
| 041 0# - LANGUAGE CODE |
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| Language code of text/sound track or separate title |
eng |
| 042 ## - AUTHENTICATION CODE |
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| Authentication code |
dc |
| 072 #7 - SUBJECT CATEGORY CODE |
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| Subject category code |
PD |
| Source |
bicssc |
| 100 1# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Jordan, Bňďicte F. |
| Relator code |
auth |
| 9 (RLIN) |
1648339 |
| 245 10 - TITLE STATEMENT |
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| Title |
Chapter 13 Targeting Tumor Perfusion and Oxygenation Modulates Hypoxia and Cancer Sensitivity to Radiotherapy and Systemic Therapies |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) |
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| Name of publisher, distributor, etc |
InTechOpen |
| Date of publication, distribution, etc |
2011 |
| 300 ## - PHYSICAL DESCRIPTION |
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| Extent |
1 online resource |
| 336 ## - |
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| -- |
text |
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txt |
| -- |
rdacontent |
| 337 ## - |
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| -- |
computer |
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c |
| -- |
rdamedia |
| 338 ## - |
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| -- |
online resource |
| -- |
cr |
| -- |
rdacarrier |
| 506 0# - RESTRICTIONS ON ACCESS NOTE |
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| Terms governing access |
Open Access |
| Standardized terminology for access restriction |
Unrestricted online access |
| Source of term |
star |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc |
Hypoxia, a partial pressure of oxygen (pO2) below physiological needs, is a limiting factor affecting the efficiency of radiotherapy. Indeed, the reaction of reactive oxygen species (ROS, produced by water radiolysis) with DNA is readily reversible unless oxygen stabilizes the DNA lesion. While normal tissue oxygenation is around 40 mm Hg, both rodent and human tumors possess regions of tissue oxygenation below 10 mm Hg, at which tumor cells become increasingly resistant to radiation damage (radiobiological hypoxia) (Gray, 1953). Because of this so-called "oxygen enhancement effect", the radiation dose required to achieve the same biologic effect is about three times higher in the absence of oxygen than in the presence of normal levels of oxygen (Gray et al., 1953; Horsman & van der Kogel, 2009). Hypoxic tumor cells, which are therefore more resistant to radiotherapy than well oxygenated ones, remain clonogenic and contribute to the therapeutic outcome of fractionated radiotherapy (Rojas et al., 1992). |
| 536 ## - FUNDING INFORMATION NOTE |
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| Text of note |
FP7 Ideas: European Research Council |
| 540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE |
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| Terms governing use and reproduction |
Creative Commons |
| -- |
https://creativecommons.org/licenses/by/3.0/ |
| -- |
cc |
| Uniform Resource Identifier |
<a href="https://creativecommons.org/licenses/by/3.0/">https://creativecommons.org/licenses/by/3.0/</a> |
| 546 ## - LANGUAGE NOTE |
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| Language note |
English |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Science: general issues |
| Source of heading or term |
bicssc |
| 9 (RLIN) |
101510 |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Blood |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
cancer sensitivity |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
cancer sensitivity |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Hemodynamics |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
hypoxia |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
hypoxia |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Magnetic resonance imaging |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Neoplasm |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Oxygen |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Perfusion |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Radiation therapy |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
radiotherapy |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
radiotherapy |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
systematic therapies |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
systematic therapies |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
tumor |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
tumor |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Vasodilation |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Sonveaux, Pierre |
| Relator code |
auth |
| 9 (RLIN) |
1574374 |
| 773 1# - HOST ITEM ENTRY |
|---|
| Title |
Advances in Cancer Therapy |
| Control subfield |
nnaa |
| Other item identifier |
OAPEN Library UUID: f8819a36-74fb-4e74-ad33-23e97c839e51 |
| 793 0# - |
|---|
| -- |
OAPEN Library. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
|---|
| Uniform Resource Identifier |
<a href="http://library.oapen.org/handle/20.500.12657/32342">http://library.oapen.org/handle/20.500.12657/32342</a> |
| -- |
0 |
| Public note |
Open Access: OAPEN Library: description of the publication |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
|---|
| Uniform Resource Identifier |
<a href="https://library.oapen.org/bitstream/id/9135c10d-07ae-40a5-955f-9830f0301d1e/612595.pdf">https://library.oapen.org/bitstream/id/9135c10d-07ae-40a5-955f-9830f0301d1e/612595.pdf</a> |
| -- |
0 |
| Public note |
Open Access: OAPEN Library, download the publication |
