MARC details
| 000 -LEADER |
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| fixed length control field |
03306namaa2200529uu 4500 |
| 001 - CONTROL NUMBER |
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| control field |
oapen49196 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
oapen |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20231220171548.0 |
| 006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS--GENERAL INFORMATION |
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| fixed length control field |
m o d |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
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| fixed length control field |
cr|mn|---annan |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
210602s2017 xx |||||o ||| 0|eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
intechopen.68526 |
| 024 7# - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
10.5772/intechopen.68526 |
| Source of number or code |
doi |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
oapen |
| Transcribing agency |
oapen |
| 041 0# - LANGUAGE CODE |
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| Language code of text/sound track or separate title |
eng |
| 042 ## - AUTHENTICATION CODE |
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| Authentication code |
dc |
| 072 #7 - SUBJECT CATEGORY CODE |
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| Subject category code |
PSAN |
| Source |
bicssc |
| 100 1# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Michael, Tolmasov |
| Relator code |
auth |
| 9 (RLIN) |
1574593 |
| 245 10 - TITLE STATEMENT |
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| Title |
Chapter Effect of Local Delivery of GDNF Conjugated Iron Oxide Nanoparticles on Nerve Regeneration along Long Chitosan Nerve Guide |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) |
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| Name of publisher, distributor, etc |
InTechOpen |
| Date of publication, distribution, etc |
2017 |
| 300 ## - PHYSICAL DESCRIPTION |
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| Extent |
1 online resource |
| 336 ## - |
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| -- |
text |
| -- |
txt |
| -- |
rdacontent |
| 337 ## - |
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| -- |
computer |
| -- |
c |
| -- |
rdamedia |
| 338 ## - |
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| -- |
online resource |
| -- |
cr |
| -- |
rdacarrier |
| 506 0# - RESTRICTIONS ON ACCESS NOTE |
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| Terms governing access |
Open Access |
| Standardized terminology for access restriction |
Unrestricted online access |
| Source of term |
star |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc |
Local delivery of neurotrophic factors is a pillar of neural repair strategies in the peripheral nervous system. The main disadvantage of the free growth factors is their short half‐life of few minutes. In previous studies, it was demonstrated that conjugation of various neurotrophic factors to iron oxide nanoparticles (IONP) led to stabilization of the growth factors and to the extension of their biological activity compared to the free factors. In vitro studies performed on organotypic dorsal root ganglion (DRG) cultures seeded in NVR gel (composed mainly of hyaluronic acid and laminin) revealed that the glial cell-derived neurotrophic factor (GDNF) conjugated to IONP‐enhanced early nerve fiber sprouting and accelerated the onset and progression of myelin significantly earlier than the free GDNF and other free and conjugated factors. The present article summarizes results of in vivo study, aimed to test the effect of free versus conjugated GDNF on regeneration of the rat sciatic nerve after a severe segment loss. We confirmed that nerve device enriched with a matrix with GDNF gives more successful results in term of regeneration and functional recovery in respect to the hollow tube; moreover, there are no detectable differences between free versus conjugated GDNF. |
| 540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE |
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| Terms governing use and reproduction |
Creative Commons |
| -- |
https://creativecommons.org/licenses/by/3.0/ |
| -- |
cc |
| Uniform Resource Identifier |
<a href="https://creativecommons.org/licenses/by/3.0/">https://creativecommons.org/licenses/by/3.0/</a> |
| 546 ## - LANGUAGE NOTE |
|---|
| Language note |
English |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Neurosciences |
| Source of heading or term |
bicssc |
| 9 (RLIN) |
2788 |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
GDNF conjugated iron oxide nanoparticles, chitosan tube, peripheral nerve regeneration |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Almog, Mara |
| Relator code |
auth |
| 9 (RLIN) |
1574594 |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Biran, Tali |
| Relator code |
auth |
| 9 (RLIN) |
1574600 |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Bitan, Yifat |
| Relator code |
auth |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Fregnan, Federica |
| Relator code |
auth |
| 9 (RLIN) |
1574602 |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Geuna, Stefano |
| Relator code |
auth |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Mandelbaum-Livnat, Mira M. |
| Relator code |
auth |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Morano, Michela |
| Relator code |
auth |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Nissan, Moshe |
| Relator code |
auth |
| 9 (RLIN) |
1574605 |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Reider, Evgeniy |
| Relator code |
auth |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Rochkind, Shimon |
| Relator code |
auth |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Shahar, Abraham |
| Relator code |
auth |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Ziv-Polat, Ofra |
| Relator code |
auth |
| 773 1# - HOST ITEM ENTRY |
|---|
| Control subfield |
nnaa |
| 793 0# - |
|---|
| -- |
OAPEN Library. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
|---|
| Uniform Resource Identifier |
<a href="https://library.oapen.org/bitstream/id/60afc120-e80d-43c5-8cb0-1233ed7ed395/54991.pdf">https://library.oapen.org/bitstream/id/60afc120-e80d-43c5-8cb0-1233ed7ed395/54991.pdf</a> |
| -- |
0 |
| Public note |
Open Access: OAPEN Library, download the publication |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
|---|
| Uniform Resource Identifier |
<a href="https://library.oapen.org/handle/20.500.12657/49196">https://library.oapen.org/handle/20.500.12657/49196</a> |
| -- |
0 |
| Public note |
Open Access: OAPEN Library: description of the publication |
