MARC details
| 000 -LEADER |
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03323namaa2200601uu 4500 |
| 001 - CONTROL NUMBER |
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oapen23759 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
oapen |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20231219170342.0 |
| 006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS--GENERAL INFORMATION |
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m o d |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
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cr|mn|---annan |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
191118s2013 xx |||||o ||| 0|eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
9783110270716 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
9783110270723.35 |
| 024 7# - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
10.1515/9783110270723.35 |
| Source of number or code |
doi |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
oapen |
| Transcribing agency |
oapen |
| 041 0# - LANGUAGE CODE |
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| Language code of text/sound track or separate title |
eng |
| 042 ## - AUTHENTICATION CODE |
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| Authentication code |
dc |
| 072 #7 - SUBJECT CATEGORY CODE |
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| Subject category code |
PHVN |
| Source |
bicssc |
| 072 #7 - SUBJECT CATEGORY CODE |
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| Subject category code |
PSAK |
| Source |
bicssc |
| 072 #7 - SUBJECT CATEGORY CODE |
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| Subject category code |
PSAN |
| Source |
bicssc |
| 072 #7 - SUBJECT CATEGORY CODE |
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| Subject category code |
PSX |
| Source |
bicssc |
| 100 1# - MAIN ENTRY--PERSONAL NAME |
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| Personal name |
Isacoff, Ehud Y. |
| Relator code |
aut |
| 9 (RLIN) |
1631149 |
| 245 10 - TITLE STATEMENT |
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| Title |
Chapter 3 Challenges and opportunities for optochemical genetics |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) |
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| Place of publication, distribution, etc |
Berlin/Boston |
| Name of publisher, distributor, etc |
De Gruyter |
| Date of publication, distribution, etc |
2013 |
| 300 ## - PHYSICAL DESCRIPTION |
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| Extent |
1 online resource |
| 336 ## - |
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| -- |
text |
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txt |
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rdacontent |
| 337 ## - |
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computer |
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c |
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rdamedia |
| 338 ## - |
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online resource |
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cr |
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rdacarrier |
| 506 0# - RESTRICTIONS ON ACCESS NOTE |
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| Terms governing access |
Free-to-read |
| Standardized terminology for access restriction |
Unrestricted online access |
| Source of term |
star |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc |
The transmembrane proteins that underlie neural processing are now known at a level of detail that has greatly increased our understanding of these sophisticated molecular machines. Starting with MacKinnon's seminal structure of a potassium channel, several voltage-gated ion channels and ionotropic receptors have been revealed with atomic resolution (Figure 3.1) [2, 3, 4, 5, 6]. This has been complemented by structures of G-protein coupled receptors, adding opsins and metabotropic receptors to the ever-increasing repertoire of transmembrane proteins elucidated with structural biology [7, 8, 9, 10]. As a consequence of this structural revolution and recent advances in pharmacology, Nature's molecular machines can now be manipulated with relative ease. This can be done, for instance, via synthetic on-off switches or tuning elements that are attached to the signaling protein of interest to allow for its orthogonal control with non-natural input signals. Amongst these signals, light is particularly useful, since it is unmatched in terms of temporal and spatial precision and techniques for the delivery and control of light are highly developed. |
| 536 ## - FUNDING INFORMATION NOTE |
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| Text of note |
FP7 Ideas: European Research Council |
| 540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE |
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| Terms governing use and reproduction |
All rights reserved |
| Uniform Resource Identifier |
<a href="http://oapen.org/content/about-rights">http://oapen.org/content/about-rights</a> |
| 546 ## - LANGUAGE NOTE |
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| Language note |
English |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Biophysics |
| Source of heading or term |
bicssc |
| 9 (RLIN) |
187768 |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Genetics (non-medical) |
| Source of heading or term |
bicssc |
| 9 (RLIN) |
926978 |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Human biology |
| Source of heading or term |
bicssc |
| 9 (RLIN) |
65210 |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Neurosciences |
| Source of heading or term |
bicssc |
| 9 (RLIN) |
2788 |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Biophysics |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Genetic Engineering |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Neuroscience |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Optics |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Vision Restoration |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Hegemann, Peter |
| Relator code |
edt |
| 9 (RLIN) |
966767 |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Hegemann, Peter |
| Relator code |
oth |
| 9 (RLIN) |
966767 |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Kramer, Richard H. |
| Relator code |
aut |
| 9 (RLIN) |
1631150 |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Sigrist, Stephan |
| Relator code |
edt |
| 9 (RLIN) |
966772 |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Sigrist, Stephan |
| Relator code |
oth |
| 9 (RLIN) |
966772 |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Trauner, Dirk |
| Relator code |
aut |
| 9 (RLIN) |
1631151 |
| 773 1# - HOST ITEM ENTRY |
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| Title |
Optogenetics |
| Control subfield |
nnaa |
| Other item identifier |
OAPEN Library UUID: 380c58bf-19b3-408c-a1b5-fb9410e1b5ed |
| 793 0# - |
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| -- |
OAPEN Library. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="http://library.oapen.org/handle/20.500.12657/23759">http://library.oapen.org/handle/20.500.12657/23759</a> |
| -- |
0 |
| Public note |
Free-to-read: OAPEN Library: description of the publication |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
|---|
| Uniform Resource Identifier |
<a href="https://library.oapen.org/bitstream/id/6cae823e-98cc-4705-af40-10f9c2199fcd/45_[9783110270723 - Optogenetics] 3 Challenges.pdf">https://library.oapen.org/bitstream/id/6cae823e-98cc-4705-af40-10f9c2199fcd/45_[9783110270723 - Optogenetics] 3 Challenges.pdf</a> |
| -- |
0 |
| Public note |
Free-to-read: OAPEN Library, download the publication |
