MARC details
| 000 -LEADER |
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| fixed length control field |
03898naaaa2200361uu 4500 |
| 001 - CONTROL NUMBER |
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| control field |
https://directory.doabooks.org/handle/20.500.12854/60862 |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20220714193731.0 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
978-2-88919-665-4 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
9782889196654 |
| 024 7# - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
10.3389/978-2-88919-665-4 |
| Terms of availability |
doi |
| 041 0# - LANGUAGE CODE |
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| Language code of text/sound track or separate title |
English |
| 042 ## - AUTHENTICATION CODE |
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| Authentication code |
dc |
| 100 1# - MAIN ENTRY--PERSONAL NAME |
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| Personal name |
Erquan Zhang |
| Relator code |
auth |
| 9 (RLIN) |
1619894 |
| 245 10 - TITLE STATEMENT |
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| Title |
Therapeutic Implications of Circadian Rhythms |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) |
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| Name of publisher, distributor, etc |
Frontiers Media SA |
| Date of publication, distribution, etc |
2015 |
| 300 ## - PHYSICAL DESCRIPTION |
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| Extent |
1 electronic resource (96 p.) |
| 506 0# - RESTRICTIONS ON ACCESS NOTE |
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| Terms governing access |
Open Access |
| Source of term |
star |
| Standardized terminology for access restriction |
Unrestricted online access |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc |
Circadian rhythms are biological processes displaying endogenous and entrainable oscillations of about 24 hours. They are driven by a group of genes called clock genes that have been widely observed in plants, animals and even in bacteria. In mammals, the core clock genes are rhythmically expressed in both the suprachiasmatic nucleus (SCN), the master clock residing in the hypothalamus, and almost all peripheral tissues where they control numerous target genes in a circadian manner, and thus affect many physiological and biochemical processes. Evidence suggests that disruption of the circadian rhythms (or desynchronization) is a significant risk factor for the development of metabolic diseases, cardiovascular diseases, cancer and sleep disorders. Evidence also suggests that the disruption suppresses immune function and increases vulnerability to infectious diseases. Restoring or strengthening the circadian rhythm may be therapeutic for these conditions. This becomes exceptionally important in modern societies because many people are suffering from frequent desynchronization due to shift working, exposure to artificial light, travel by transmeridian air flight, and involvement in social activities. Besides, the temporal variations in the incidence and severity of many diseases, such as the onset of cardiovascular events, chronic obstructive pulmonary disease (COPD), inflammatory diseases and mental disorders have also drawn increasing attention to the circadian clock. The circadian rhythms affect not only the health status, but also the drug efficiency. The effects (and side effects) of many drugs vary with biological timing. The tolerance of many medications displays circadian variation as well. The timing of medical treatment in coordination with the body clock may significantly increase the desired effects of drugs, and lower the dose and toxicity. In addition, circadian rhythms can also be modulated by some therapeutic drugs, for example, melatonin and modafinil, which are used to treat circadian rhythm sleep disorders. In this Research Topic, we assemble a series of critical review and research articles that focus on the therapeutic implications of circadian rhythms. Topics include, but are not limited to: • Circadian disruption caused diseases or disorders and related intervention • Temporal manifestation of diseases or disorders and therapeutic implications • The effects of circadian rhythms on drugs • The effects of drugs on circadian rhythms |
| 540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE |
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| Terms governing use and reproduction |
Creative Commons |
| -- |
https://creativecommons.org/licenses/by/4.0/ |
| -- |
cc |
| -- |
https://creativecommons.org/licenses/by/4.0/ |
| 546 ## - LANGUAGE NOTE |
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| Language note |
English |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Cardiovascular Diseases |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Central Nervous System |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Therapeutic implications |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Circadian Clocks |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Clinical relevance |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Circadian Rhythm |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Metabolism |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
circadian disruption |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Guangrui Yang |
| Relator code |
auth |
| 9 (RLIN) |
1619895 |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Han Wang |
| Relator code |
auth |
| 9 (RLIN) |
1619896 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
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| Host name |
www.oapen.org |
| Uniform Resource Identifier |
<a href="http://journal.frontiersin.org/researchtopic/3098/therapeutic-implications-of-circadian-rhythms">http://journal.frontiersin.org/researchtopic/3098/therapeutic-implications-of-circadian-rhythms</a> |
| -- |
0 |
| Public note |
DOAB: download the publication |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
|---|
| Host name |
www.oapen.org |
| Uniform Resource Identifier |
<a href="https://directory.doabooks.org/handle/20.500.12854/60862">https://directory.doabooks.org/handle/20.500.12854/60862</a> |
| -- |
0 |
| Public note |
DOAB: description of the publication |
