MARC details
| 000 -LEADER |
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| fixed length control field |
04138naaaa2200889uu 4500 |
| 001 - CONTROL NUMBER |
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| control field |
https://directory.doabooks.org/handle/20.500.12854/69300 |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20220714185655.0 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
books978-3-03943-490-9 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
9783039434893 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
9783039434909 |
| 024 7# - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
10.3390/books978-3-03943-490-9 |
| Terms of availability |
doi |
| 041 0# - LANGUAGE CODE |
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| Language code of text/sound track or separate title |
English |
| 042 ## - AUTHENTICATION CODE |
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| Authentication code |
dc |
| 072 #7 - SUBJECT CATEGORY CODE |
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| Subject category code |
M |
| Source |
bicssc |
| 100 1# - MAIN ENTRY--PERSONAL NAME |
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| Personal name |
Hirbe, Angela C. |
| Relator code |
edt |
| 9 (RLIN) |
1608912 |
| 245 10 - TITLE STATEMENT |
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| Title |
Genomics and Models of Nerve Sheath Tumors |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) |
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| Place of publication, distribution, etc |
Basel, Switzerland |
| Name of publisher, distributor, etc |
MDPI - Multidisciplinary Digital Publishing Institute |
| Date of publication, distribution, etc |
2020 |
| 300 ## - PHYSICAL DESCRIPTION |
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| Extent |
1 electronic resource (172 p.) |
| 506 0# - RESTRICTIONS ON ACCESS NOTE |
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| Terms governing access |
Open Access |
| Source of term |
star |
| Standardized terminology for access restriction |
Unrestricted online access |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc |
Nerve sheath tumors can be a significant cause of morbidity for many patients. These include benign tumors such as schwannomas, diffuse and plexiform neurofibromas, and atypical neurofibromas, as well as the aggressive soft tissue sarcoma known as the malignant peripheral nerve sheath tumor (MPNST). Nerve sheath tumors occur sporadically and in the context of the clinical neuro-genetic tumor predisposition syndromes neurofibromatosis type 1 (NF1) and type 2 (NF2). Historically, the mainstay of treatment for nerve sheath tumors has been surgery. However, for both benign and malignant nerve sheath tumors, there is a high recurrence rate, highlighting the pressing need for novel therapies. As we have entered the genomic era, the hope is that an improved understanding of the genetics, and therefore the biology, of these tumors will ultimately lead to therapies that result in better outcomes. In this Special Issue, we include both review articles and original research related to the genomic understanding and modeling of schwannomas, plexiform and diffuse neurofibromas, atypical neurofibromas, and malignant peripheral nerve sheath tumors as well as genomic methods being developed and applied to advance our understanding of these tumors. |
| 540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE |
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| Terms governing use and reproduction |
Creative Commons |
| -- |
https://creativecommons.org/licenses/by/4.0/ |
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cc |
| -- |
https://creativecommons.org/licenses/by/4.0/ |
| 546 ## - LANGUAGE NOTE |
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| Language note |
English |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Medicine |
| Source of heading or term |
bicssc |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
neurofibromatosis type 1 |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
nerve sheath tumor |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
cancer |
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| Uncontrolled term |
latent variables |
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machine learning |
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supervised learning |
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transfer learning |
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random forest |
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| Uncontrolled term |
metaVIPER |
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| Uncontrolled term |
tumor deconvolution |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
neurofibromatosis |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
malignant peripheral nerve sheath tumor |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
MPNST |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
polycomb repressive complex |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
PRC2 |
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| Uncontrolled term |
NF1 |
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| Uncontrolled term |
kinase |
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| Uncontrolled term |
kinome adaptation |
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| Uncontrolled term |
kinome reprogramming |
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| Uncontrolled term |
MET |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
MEK |
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| Uncontrolled term |
doxorubicin |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
capmatinib |
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| Uncontrolled term |
tram |
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| Uncontrolled term |
genomics |
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| Uncontrolled term |
tumor evolution |
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| Uncontrolled term |
pathology |
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| Uncontrolled term |
next generation sequencing |
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| Uncontrolled term |
clinical genetics |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
malignant peripheral nerve sheath tumors |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
plexiform neurofibromas |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Schwann cells |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
neurofibromatosis type 1 syndrome |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
neurofibromin 1 |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
genetically engineered mouse models |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
heterogeneity |
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| Uncontrolled term |
CRISPR/Cas9 |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
mouse models |
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| Uncontrolled term |
sarcoma |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
tumor microenvironment |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
neurofibromatosis 1 (NF1) |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
mebendazole (MBZ) |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
COX-2 inhibitor |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
malignancy |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
chemoprevention |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
nerve sheath tumors |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Pratilas, Christine A. |
| Relator code |
edt |
| 9 (RLIN) |
1608913 |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Dodd, Rebecca D. |
| Relator code |
edt |
| 9 (RLIN) |
1608914 |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Hirbe, Angela C. |
| Relator code |
oth |
| 9 (RLIN) |
1608912 |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Pratilas, Christine A. |
| Relator code |
oth |
| 9 (RLIN) |
1608913 |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Dodd, Rebecca D. |
| Relator code |
oth |
| 9 (RLIN) |
1608914 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
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| Host name |
www.oapen.org |
| Uniform Resource Identifier |
<a href="https://mdpi.com/books/pdfview/book/3090">https://mdpi.com/books/pdfview/book/3090</a> |
| -- |
0 |
| Public note |
DOAB: download the publication |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
|---|
| Host name |
www.oapen.org |
| Uniform Resource Identifier |
<a href="https://directory.doabooks.org/handle/20.500.12854/69300">https://directory.doabooks.org/handle/20.500.12854/69300</a> |
| -- |
0 |
| Public note |
DOAB: description of the publication |
