MARC details
| 000 -LEADER |
|---|
| fixed length control field |
04564naaaa2200373uu 4500 |
| 001 - CONTROL NUMBER |
|---|
| control field |
https://directory.doabooks.org/handle/20.500.12854/46250 |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
|---|
| control field |
20220714185158.0 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
|---|
| International Standard Book Number |
978-2-88919-642-5 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
|---|
| International Standard Book Number |
9782889196425 |
| 024 7# - OTHER STANDARD IDENTIFIER |
|---|
| Standard number or code |
10.3389/978-2-88919-642-5 |
| Terms of availability |
doi |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
English |
| 042 ## - AUTHENTICATION CODE |
|---|
| Authentication code |
dc |
| 100 1# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Tarek A. Leil |
| Relator code |
auth |
| 9 (RLIN) |
1607449 |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
The Emerging Discipline of Quantitative Systems Pharmacology |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) |
|---|
| Name of publisher, distributor, etc |
Frontiers Media SA |
| Date of publication, distribution, etc |
2015 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
1 electronic resource (97 p.) |
| 506 0# - RESTRICTIONS ON ACCESS NOTE |
|---|
| Terms governing access |
Open Access |
| Source of term |
star |
| Standardized terminology for access restriction |
Unrestricted online access |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc |
In 2011, the National Institutes of Health (NIH), in collaboration with leaders from the pharmaceutical industry and the academic community, published a white paper describing the emerging discipline of Quantitative Systems Pharmacology (QSP), and recommended the establishment of NIH-supported interdisciplinary research and training programs for QSP. QSP is still in its infancy, but has tremendous potential to change the way we approach biomedical research. QSP is really the integration of two disciplines that have been increasingly useful in biomedical research; "Systems Biology" and "Quantitative Pharmacology". Systems Biology is the field of biomedical research that seeks to understand the relationships between genes and biologically active molecules to develop qualitative models of these systems; and Quantitative Pharmacology is the field of biomedical research that seeks to use computer aided modeling and simulation to increase our understanding of the pharmacokinetics (PK) and pharmacodynamics (PD) of drugs, and to aid in the design of pre-clinical and clinical experiments. The purpose of QSP modeling is to develop quantitative computer models of biological systems and disease processes, and the effects of drug PK and PD on those systems. QSP models allow testing of numerous potential experiments "in-silico" to eliminate those associated with a low probability of success, avoiding the potential costs of evaluating all of those failed experiments in the real world. At the same time, QSP models allow us to develop our understanding of the interaction between drugs and biological systems in a more systematic and rigorous manner. As the need to be more cost-efficient in the use of research funding increases, biomedical researchers will be required to gain the maximum insight from each experiment that is conducted. This need is even more acute in the pharmaceutical industry, where there is tremendous competition to develop innovative therapies in a highly regulated environment, combined with very high research and development (R&D) costs for bringing new drugs to market (~$1.3 billion/drug). Analogous modeling & simulation approaches have been successfully integrated into other disciplines to improve the fundamental understanding of the science and to improve the efficiency of R&D (e.g., physics, engineering, economics, etc.). The biomedical research community has been slow to integrate computer aided modeling & simulation for many reasons: including the perception that biology and pharmacology are "too complex" and "too variable" to be modeled with mathematical equations; a lack of adequate graduate training programs; and the lack of support from government agencies that fund biomedical research. However, there is an active community of researchers in the pharmaceutical industry, the academic community, and government agencies that develop QSP and quantitative systems biology models and apply them both to better characterize and predict drug pharmacology and disease processes; as well as to improve efficiency and productivity in pharmaceutical R&D. |
| 540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE |
|---|
| Terms governing use and reproduction |
Creative Commons |
| -- |
https://creativecommons.org/licenses/by/4.0/ |
| -- |
cc |
| -- |
https://creativecommons.org/licenses/by/4.0/ |
| 546 ## - LANGUAGE NOTE |
|---|
| Language note |
English |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Pharmacodynamics |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
In-silico |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
pharmacometrics |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Pharmaceutical R&D |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Computational Biology |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
pharmacokinetics |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Quantitative Systems Pharmacology |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Modeling & Simulation |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Multi-scale modeling |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Systems Biology |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Sergey Ermakov |
| Relator code |
auth |
| 9 (RLIN) |
1607450 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
|---|
| Host name |
www.oapen.org |
| Uniform Resource Identifier |
<a href="http://journal.frontiersin.org/researchtopic/2103/the-emerging-discipline-of-quantitative-systems-pharmacology">http://journal.frontiersin.org/researchtopic/2103/the-emerging-discipline-of-quantitative-systems-pharmacology</a> |
| -- |
0 |
| Public note |
DOAB: download the publication |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
|---|
| Host name |
www.oapen.org |
| Uniform Resource Identifier |
<a href="https://directory.doabooks.org/handle/20.500.12854/46250">https://directory.doabooks.org/handle/20.500.12854/46250</a> |
| -- |
0 |
| Public note |
DOAB: description of the publication |
