MARC details
| 000 -LEADER |
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| fixed length control field |
04774naaaa2200373uu 4500 |
| 001 - CONTROL NUMBER |
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| control field |
https://directory.doabooks.org/handle/20.500.12854/62652 |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20220714185020.0 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
978-2-88919-928-0 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
9782889199280 |
| 024 7# - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
10.3389/978-2-88919-928-0 |
| Terms of availability |
doi |
| 041 0# - LANGUAGE CODE |
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| Language code of text/sound track or separate title |
English |
| 042 ## - AUTHENTICATION CODE |
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| Authentication code |
dc |
| 100 1# - MAIN ENTRY--PERSONAL NAME |
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| Personal name |
Erich Kombrink |
| Relator code |
auth |
| 9 (RLIN) |
1606987 |
| 245 10 - TITLE STATEMENT |
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| Title |
When Chemistry Meets Biology - Generating Innovative Concepts, Methods and Tools for Scientific Discovery in the Plant Sciences |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) |
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| Name of publisher, distributor, etc |
Frontiers Media SA |
| Date of publication, distribution, etc |
2016 |
| 300 ## - PHYSICAL DESCRIPTION |
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| Extent |
1 electronic resource (146 p.) |
| 506 0# - RESTRICTIONS ON ACCESS NOTE |
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| Terms governing access |
Open Access |
| Source of term |
star |
| Standardized terminology for access restriction |
Unrestricted online access |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc |
Biologically active small molecules have increasingly been applied in plant biology to dissect and understand biological systems. This is evident from the frequent use of potent and selective inhibitors of enzymes or other biological processes such as transcription, translation, or protein degradation. In contrast to animal systems, which are nurtured from drug research, the systematic development of novel bioactive small molecules as research tools for plant systems is a largely underexplored research area. This is surprising since bioactive small molecules bear great potential for generating new, powerful tools for dissecting diverse biological processes. In particular, when small molecules are integrated into genetic strategies (thereby defining "chemical genetics"), they may help to circumvent inherent problems of classical (forward) genetics. There are now clear examples of important, fundamental discoveries originating from plant chemical genetics that demonstrate the power, but not yet fully exploited potential, of this experimental approach. These include the unraveling of molecular mechanisms and critical steps in hormone signaling, activation of defense reactions and dynamic intracellular processes. The intention of this Research Topic of Frontiers in Plant Physiology is to summarize the current status of research at the interface between chemistry and biology and to identify future research challenges. The research topic covers diverse aspects of plant chemical biology, including the identification of bioactive small molecules through screening processes from chemical libraries and natural sources, which rely on robust and quantitative high-throughput bioassays, the critical evaluation and characterization of the compound's activity (selectivity) and, ultimately, the identification of its protein target(s) and mode-of-action, which is yet the biggest challenge of all. Such well-characterized, selective chemicals are attractive tools for basic research, allowing the functional dissection of plant signaling processes, or for applied purposes, if designed for protection of crop plants from disease. New methods and data mining tools for assessing the bioactivity profile of compounds, exploring the chemical space for structure-function relationships, and comprehensive chemical fingerprinting (metabolomics) are also important strategies in plant chemical biology. In addition, there is a continuing need for diverse target-specific bioprobes that help profiling enzymatic activities or selectively label protein complexes or cellular compartments. To achieve these goals and to add suitable probes and methods to the experimental toolbox, plant biologists need to closely cooperate with synthetic chemists. The development of such tailored chemicals that beyond application in basic research can modify traits of crop plants or target specific classes of weeds or pests by collaboration of applied and academic research groups may provide a bright future for plant chemical biology. The current Research Topic covers the breadth of the field by presenting original research articles, methods papers, reviews, perspectives and opinions. |
| 540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE |
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| Terms governing use and reproduction |
Creative Commons |
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https://creativecommons.org/licenses/by/4.0/ |
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cc |
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https://creativecommons.org/licenses/by/4.0/ |
| 546 ## - LANGUAGE NOTE |
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| Language note |
English |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Plant-pathogen interaction |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
High-Throughput Screening |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
agricultural biotechnology |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
plant growth regulator |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Chemical Genetics |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
bioactive small molecule |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Target identification |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Chemical Biology |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Plant immune response |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
phytohormone |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Markus Kaiser |
| Relator code |
auth |
| 9 (RLIN) |
1606988 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
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| Host name |
www.oapen.org |
| Uniform Resource Identifier |
<a href="http://journal.frontiersin.org/researchtopic/2002/when-chemistry-meets-biology---generating-innovative-concepts-methods-and-tools-for-scientific-disco">http://journal.frontiersin.org/researchtopic/2002/when-chemistry-meets-biology---generating-innovative-concepts-methods-and-tools-for-scientific-disco</a> |
| -- |
0 |
| Public note |
DOAB: download the publication |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
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| Host name |
www.oapen.org |
| Uniform Resource Identifier |
<a href="https://directory.doabooks.org/handle/20.500.12854/62652">https://directory.doabooks.org/handle/20.500.12854/62652</a> |
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0 |
| Public note |
DOAB: description of the publication |
