MARC details
| 000 -LEADER |
|---|
| fixed length control field |
02394naaaa2200325uu 4500 |
| 001 - CONTROL NUMBER |
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| control field |
https://directory.doabooks.org/handle/20.500.12854/42868 |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
|---|
| control field |
20220714184824.0 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
books978-3-03842-703-2 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
|---|
| International Standard Book Number |
9783038427032 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
|---|
| International Standard Book Number |
9783038427049 |
| 024 7# - OTHER STANDARD IDENTIFIER |
|---|
| Standard number or code |
10.3390/books978-3-03842-703-2 |
| Terms of availability |
doi |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
English |
| 042 ## - AUTHENTICATION CODE |
|---|
| Authentication code |
dc |
| 100 1# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Alexey S. Ladokhin (Ed.) |
| Relator code |
auth |
| 9 (RLIN) |
1606385 |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Cellular Entry of Binary and Pore-Forming Bacterial Toxins |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) |
|---|
| Name of publisher, distributor, etc |
MDPI - Multidisciplinary Digital Publishing Institute |
| Date of publication, distribution, etc |
2018 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
1 electronic resource (128 p.) |
| 506 0# - RESTRICTIONS ON ACCESS NOTE |
|---|
| Terms governing access |
Open Access |
| Source of term |
star |
| Standardized terminology for access restriction |
Unrestricted online access |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc |
Bridging cellular membranes is a key step in the pathogenic action of both binary and pore-forming bacterial toxins. The former use their translocation domains, containing various structural motifs, to ensure efficient delivery of the toxic component into the host cell, while the latter act on the cellular membrane itself. In either case, the integrity of the membrane is compromised via targeted protein-lipid and protein-protein interactions triggered by specific signals, such as proteolytic cleavage or endosomal acidification. This Special Issue presents recent advances in characterizing functional, structural and thermodynamic aspects of the conformational switching and membrane interactions involved in the cellular entry of bacterial protein toxins. Deciphering the physicochemical principles underlying these processes is also a prerequisite for the use of protein engineering to develop toxin-based molecular vehicles capable of targeted delivery of therapeutic agents to tumors and other diseased tissues. |
| 540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE |
|---|
| Terms governing use and reproduction |
Creative Commons |
| -- |
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| -- |
cc |
| -- |
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| 546 ## - LANGUAGE NOTE |
|---|
| Language note |
English |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
membrane permeabilization and translocation |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
toxin-membrane interactions |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
bacterial protein toxins |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
conformational switching |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
toxin-based targeted delivery of therapeutic agents |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
cellular uptake |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
|---|
| Host name |
www.oapen.org |
| Uniform Resource Identifier |
<a href="http://www.mdpi.com/books/pdfview/book/531">http://www.mdpi.com/books/pdfview/book/531</a> |
| -- |
0 |
| Public note |
DOAB: download the publication |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
|---|
| Host name |
www.oapen.org |
| Uniform Resource Identifier |
<a href="https://directory.doabooks.org/handle/20.500.12854/42868">https://directory.doabooks.org/handle/20.500.12854/42868</a> |
| -- |
0 |
| Public note |
DOAB: description of the publication |
