MARC details
| 000 -LEADER |
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| fixed length control field |
04873naaaa2201129uu 4500 |
| 001 - CONTROL NUMBER |
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| control field |
https://directory.doabooks.org/handle/20.500.12854/76476 |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20220714184602.0 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
books978-3-0365-0563-3 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
9783036505626 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
9783036505633 |
| 024 7# - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
10.3390/books978-3-0365-0563-3 |
| Terms of availability |
doi |
| 041 0# - LANGUAGE CODE |
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| Language code of text/sound track or separate title |
English |
| 042 ## - AUTHENTICATION CODE |
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| Authentication code |
dc |
| 072 #7 - SUBJECT CATEGORY CODE |
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| Subject category code |
M |
| Source |
bicssc |
| 100 1# - MAIN ENTRY--PERSONAL NAME |
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| Personal name |
Ciarimboli, Giuliano |
| Relator code |
edt |
| 9 (RLIN) |
1605882 |
| 245 10 - TITLE STATEMENT |
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| Title |
Physiology, Biochemistry, and Pharmacology of Transporters for Organic Cations |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) |
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| Place of publication, distribution, etc |
Basel, Switzerland |
| Name of publisher, distributor, etc |
MDPI - Multidisciplinary Digital Publishing Institute |
| Date of publication, distribution, etc |
2021 |
| 300 ## - PHYSICAL DESCRIPTION |
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| Extent |
1 electronic resource (248 p.) |
| 506 0# - RESTRICTIONS ON ACCESS NOTE |
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| Terms governing access |
Open Access |
| Source of term |
star |
| Standardized terminology for access restriction |
Unrestricted online access |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc |
Membrane transporters are of vital importance for cells. They mediate the flux of many substances through the plasma membrane. In this book, the transporters for organic cations, a special class of membrane transporters, are presented. Transporters belonging to this class are important because they allow many neurotransmitters (e.g., histamine and serotonin) and many drugs (e.g., trospium and tofacitinib) to permeate the plasma membrane. Therefore, transporters for organic cations can modulate the action of neurotransmitters and drugs, having in this way important physiological and pharmacological implications. These aspects are illustrated in original works and reviews presented in this book. Using a system biology approach, the global significance of different transporters working together has been illustrated. Regulation mechanisms determining their expression in specific organs and modulating their function are also described in this book, also concerning their role for special drug toxicities. Such an aspect is also discussed in relationship to mutations (single nucleotide polymorphisms) of transporters for organic cations. Finally, the translational value of studies performed in flies, mice, and rats is discussed. Therefore, this book offers integrative information on transporters for organic cations, which may be of interest to beginners and specialized scientists in this field. |
| 540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE |
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| Terms governing use and reproduction |
Creative Commons |
| -- |
https://creativecommons.org/licenses/by/4.0/ |
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cc |
| -- |
https://creativecommons.org/licenses/by/4.0/ |
| 546 ## - LANGUAGE NOTE |
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| Language note |
English |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Medicine |
| Source of heading or term |
bicssc |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
transporters |
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| Uncontrolled term |
endogenous metabolism |
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| Uncontrolled term |
functional subgroups |
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SLC22 |
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| Uncontrolled term |
remote sensing and signaling |
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| Uncontrolled term |
drug transporters |
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| Uncontrolled term |
gut microbiome |
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| Uncontrolled term |
chronic kidney disease |
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| Uncontrolled term |
solute carrier 22 (SLC22) |
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| Uncontrolled term |
Remote Sensing and Signaling Theory |
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| Uncontrolled term |
interorgan communication |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
organic anion transporter |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
organic cation transporter |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
SLC22A15 |
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| Uncontrolled term |
SLC22A16 |
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SLC22A18 |
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kidney |
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Malpighian tubule |
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TCGA |
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human pathology atlas |
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gene ontology |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
organic cations |
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| Uncontrolled term |
transport |
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| Uncontrolled term |
kidneys |
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regulation |
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Nuclear receptor |
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renal excretion |
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| Uncontrolled term |
bile acids |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
organic cation transporters |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
drug disposition |
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| Uncontrolled term |
genetic polymorphisms |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
drug-induced kidney injury |
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| Uncontrolled term |
nephrotoxicity |
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| Uncontrolled term |
RA |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Tofacitinib |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Baricitinib |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
MATE1 |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
solute carrier (SLC) family |
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OCT1 |
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| Uncontrolled term |
SLC22A1 |
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| Uncontrolled term |
species differences |
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| Uncontrolled term |
drugs |
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| Uncontrolled term |
pesticides |
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| Uncontrolled term |
cisplatin nephrotoxicity |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
PPAR-alpha |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
organic transporters |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
serotonin transporter |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
plasma membrane monoamine transporter |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
ketamine |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
isoflurane |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
serotonin clearance |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
antidepressant-like activity |
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| Uncontrolled term |
chronoamperometry |
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| Uncontrolled term |
tail suspension test |
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| Uncontrolled term |
forced swim test |
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| Uncontrolled term |
hepatotoxicity |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
solute carrier |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
pulmonary drug delivery |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
SLC22A1-5 |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
lung epithelium |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
drug uptake |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
β2-agonists |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
chronic lung diseases |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
anticholinergics |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
trospium |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
OCT |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
MATE |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
drug excretion |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
drug transport |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
n/a |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Ciarimboli, Giuliano |
| Relator code |
oth |
| 9 (RLIN) |
1605882 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
|---|
| Host name |
www.oapen.org |
| Uniform Resource Identifier |
<a href="https://mdpi.com/books/pdfview/book/3912">https://mdpi.com/books/pdfview/book/3912</a> |
| -- |
0 |
| Public note |
DOAB: download the publication |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
|---|
| Host name |
www.oapen.org |
| Uniform Resource Identifier |
<a href="https://directory.doabooks.org/handle/20.500.12854/76476">https://directory.doabooks.org/handle/20.500.12854/76476</a> |
| -- |
0 |
| Public note |
DOAB: description of the publication |
