MARC details
| 000 -LEADER |
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| fixed length control field |
03887naaaa2200361uu 4500 |
| 001 - CONTROL NUMBER |
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| control field |
https://directory.doabooks.org/handle/20.500.12854/41778 |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20220714184130.0 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
978-2-88919-931-0 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
9782889199310 |
| 024 7# - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
10.3389/978-2-88919-931-0 |
| Terms of availability |
doi |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
English |
| 042 ## - AUTHENTICATION CODE |
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| Authentication code |
dc |
| 100 1# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Hiroshi Nikaido |
| Relator code |
auth |
| 9 (RLIN) |
1604881 |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Bad Bugs in the XXIst Century: Resistance Mediated by Multi-Drug Efflux Pumps in Gram-Negative Bacteria |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) |
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| Name of publisher, distributor, etc |
Frontiers Media SA |
| Date of publication, distribution, etc |
2016 |
| 300 ## - PHYSICAL DESCRIPTION |
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| Extent |
1 electronic resource (193 p.) |
| 506 0# - RESTRICTIONS ON ACCESS NOTE |
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| Terms governing access |
Open Access |
| Source of term |
star |
| Standardized terminology for access restriction |
Unrestricted online access |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc |
The discovery of antibiotics represented a key milestone in the history of medicine. However, with the rise of these life-saving drugs came the awareness that bacteria deploy defence mechanisms to resist these antibiotics, and they are good at it. Today, we appear at a crossroads between discovery of new potent drugs and omni-resistant superbugs. Moreover, the misuse of antibiotics in different industries has increased the rate of resistance development by providing permanent selective pressure and, subsequently, enrichment of multidrug resistant pathogens. As a result, antimicrobial resistance has now become an urgent threat to public health worldwide (http://www.who.int/drugresistance/documents/surveillancereport/en/). The development of multidrug resistance (MDR) in an increasing number of pathogens, including Pseudomonas, Acinetobacter, Klebsiella, Salmonella, Burkholderia, and other Gram-negative bacteria is a most severe issue. Membrane efflux pump complexes of the Resistance-Nodulation-cell Division (RND) superfamily play a key role in the development of MDR in these bacteria. RND pumps, together with other transporters, contribute to intrinsic and acquired resistance to most, if not all, of the antimicrobial compounds available in our drug arsenal. Given the enormous drug polyspecificity of MDR efflux pumps, studies on their mechanism of action are extremely challenging, and this has negatively impacted both the development of new antibiotics that are able to evade these efflux pumps as well as the design of pump inhibitors. The collection of articles in this eBook, published as a Research Topic in Frontiers in Microbiology, section of Antimicrobials, Resistance, and Chemotherapy, aims to update the reader about the latest advances on the structure and function of RND efflux transporters, their roles in the overall multidrug resistance phenotype of Gram-negative pathogens, and on strategies to inhibit their activities. A deeper understanding of the mechanisms by which RND efflux pumps, alone or synergistically with other efflux pumps, are able to limit the concentration of antimicrobial compounds inside the bacterial cell, may pave the way for new, more directed, inhibitor and antibiotic design to ultimately overcome antimicrobial resistance by Gram-negatives. |
| 540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE |
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| Terms governing use and reproduction |
Creative Commons |
| -- |
https://creativecommons.org/licenses/by/4.0/ |
| -- |
cc |
| -- |
https://creativecommons.org/licenses/by/4.0/ |
| 546 ## - LANGUAGE NOTE |
|---|
| Language note |
English |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Resistance-Nodulation Division transporters |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
multi-drug-resistant pathogens |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
antibiotic resistance |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Gram-Negative Bacteria |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
bacterial resistance mechanisms |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Superbugs |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
efflux pumps |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Attilio Vittorio Vargiu |
| Relator code |
auth |
| 9 (RLIN) |
1604882 |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Klaas Martinus Pos |
| Relator code |
auth |
| 9 (RLIN) |
1604883 |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Keith Poole |
| Relator code |
auth |
| 9 (RLIN) |
1604884 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
|---|
| Host name |
www.oapen.org |
| Uniform Resource Identifier |
<a href="http://journal.frontiersin.org/researchtopic/2904/bad-bugs-in-the-xxist-century-resistance-mediated-by-multi-drug-efflux-pumps-in-gram-negative-bacter">http://journal.frontiersin.org/researchtopic/2904/bad-bugs-in-the-xxist-century-resistance-mediated-by-multi-drug-efflux-pumps-in-gram-negative-bacter</a> |
| -- |
0 |
| Public note |
DOAB: download the publication |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
|---|
| Host name |
www.oapen.org |
| Uniform Resource Identifier |
<a href="https://directory.doabooks.org/handle/20.500.12854/41778">https://directory.doabooks.org/handle/20.500.12854/41778</a> |
| -- |
0 |
| Public note |
DOAB: description of the publication |
