MARC details
000 -LEADER |
fixed length control field |
07346naaaa2202101uu 4500 |
001 - CONTROL NUMBER |
control field |
https://directory.doabooks.org/handle/20.500.12854/68429 |
005 - DATE AND TIME OF LATEST TRANSACTION |
control field |
20220714180952.0 |
020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
International Standard Book Number |
books978-3-0365-0141-3 |
020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
International Standard Book Number |
9783036501406 |
020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
International Standard Book Number |
9783036501413 |
024 7# - OTHER STANDARD IDENTIFIER |
Standard number or code |
10.3390/books978-3-0365-0141-3 |
Terms of availability |
doi |
041 0# - LANGUAGE CODE |
Language code of text/sound track or separate title |
English |
042 ## - AUTHENTICATION CODE |
Authentication code |
dc |
072 #7 - SUBJECT CATEGORY CODE |
Subject category code |
M |
Source |
bicssc |
100 1# - MAIN ENTRY--PERSONAL NAME |
Personal name |
Chen, Qiao-Hong |
Relator code |
edt |
9 (RLIN) |
1597909 |
245 10 - TITLE STATEMENT |
Title |
Anticancer Agents : Design, Synthesis and Evaluation |
260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) |
Place of publication, distribution, etc |
Basel, Switzerland |
Name of publisher, distributor, etc |
MDPI - Multidisciplinary Digital Publishing Institute |
Date of publication, distribution, etc |
2021 |
300 ## - PHYSICAL DESCRIPTION |
Extent |
1 electronic resource (606 p.) |
506 0# - RESTRICTIONS ON ACCESS NOTE |
Terms governing access |
Open Access |
Source of term |
star |
Standardized terminology for access restriction |
Unrestricted online access |
520 ## - SUMMARY, ETC. |
Summary, etc |
This book is a printed edition of the Special Issue entitled "Anticancer Agents: Design, Synthesis and Evaluation" that was published in Molecules. Two review articles and thirty research papers are included in the Special Issue. Three second-generation androgen receptor antagonists that have been approved by the U.S. FDA for the treatment of prostate cancer have been reviewed. Identification of mimics of protein partners as protein-protein interaction inhibitors via virtual screening has been summarized and discussed. Anticancer agents targeting various protein targets, including IGF-1R, Src, protein kinase, aromatase, HDAC, PARP, Toll-Like receptor, c-Met, PI3Kdelta, topoisomerase II, p53, and indoleamine 2,3-dioxygenase, have been explored. The analogs of three well-known tubulin-interacting natural products, paclitaxel, zampanolide, and colchicine, have been designed, synthesized, and evaluated. Several anticancer agents representing diverse chemical scaffolds were assessed in different kinds of cancer cell models. The capability of some anticancer agents to overcome the resistance to currently available drugs was also studied. In addition to looking into the in vitro ability of the anticancer agents to inhibit cancer cell proliferation, apoptosis, and cell cycle, in vivo antitumor efficacy in animal models and DFT were also investigated in some papers. |
540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE |
Terms governing use and reproduction |
Creative Commons |
-- |
https://creativecommons.org/licenses/by/4.0/ |
-- |
cc |
-- |
https://creativecommons.org/licenses/by/4.0/ |
546 ## - LANGUAGE NOTE |
Language note |
English |
650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name as entry element |
Medicine |
Source of heading or term |
bicssc |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
benzofurans |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
chemical synthesis |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
cytotoxic properties |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
HeLa |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
MOLT-4 |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
K562 |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
anticancer |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
anti-neuroinflammation |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
coumarin |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
dihydroartemisinin |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
flavonoids |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
allene |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
E-stereoselective |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
regioselective |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
anti-cancer activity |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
cyanopyridone |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
substituted pyridine |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
pyridotriazine |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
pyrazolopyridine |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
thioxotriazopyridine |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
anticancer activity |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
HepG2 |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
antitumor activity |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
computational docking |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
MDM2-p53 interaction |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
xanthones |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
yeast-based assays |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
estrone derivatives |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
hydrazine |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
N-substituted pyrazoline |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
anti-ovarian cancer |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
topoisomerase II inhibitor |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
kinase inhibitor |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
antiproliferative agent |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
urea |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
synthesis |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
antiproliferative activity |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
apoptosis |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
indoleamine 2,3-dioxygenase |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
inhibitor |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
anti-tumor |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
immune modulation |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
tryptophan metabolism |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
taxoids |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
βIII-tubulin |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
P-glycoprotein |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
drug resistance |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
thiopene |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
thienopyrimidinone |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
thiazolidinone |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
breast cancer |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
benzofuran-pyrazole |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
nanoparticles |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
cytotoxic activity |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
PARP-1 inhibition |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
3,6-dibromocarbazole |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
5-bromoindole |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
carbazole |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
actin |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
migration |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
Thienopyrimidine |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
Pyrazole |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
PI3Kα inhibitor |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
quinazolin-4(3H)-one |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
quinazolin-4(3H)-thione |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
Schiff base |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
antioxidant activity |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
DFT study |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
ortho-quinones |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
beta-lapachone |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
tanshione IIA |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
PI3Ks |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
PI3Kδ inhibitors |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
2H-benzo[e][1,2,4]thiadiazine 1,1-dioxide |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
anticancer agents |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
protein-protein interactions |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
virtual screening |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
mimetics |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
drug discovery |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
bivalency |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
polyvalency |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
antitumor |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
cell cycle |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
ovarian cancer |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
P-MAPA |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
IL-12 |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
TLR signaling |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
inflammation |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
chemoresistance |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
4-(pyridin-4-yloxy)benzamide |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
1,2,3-triazole |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
c-Met |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
natural product |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
anticancer agent |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
zampanolide |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
Talazoparib |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
PARP inhibitor |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
prodrug |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
o-nitro-benzyl |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
photoactivatable protecting groups |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
salinomycin |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
overcoming drug resistance |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
tumor specificity |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
synergy |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
5-fluorouracil |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
gemcitabine |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
amides/esters |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
colchicine analogs |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
thiocolchicine |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
colchiceine |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
antimitotic agents |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
hydrates |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
dihydropyranoindole |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
HDAC inhibitors |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
neuroblastoma |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
aromatase |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
MCF-7 |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
NIH3T3 |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
benzimidazole |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
triazolothiadiazine |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
docking |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
ADME |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
organosilicon compounds |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
SILA-409 (Alis-409) |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
SILA-421 (Alis-421) |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
multidrug resistance (MDR) reversal |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
ABCB1 (P-glycoprotein) |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
colon cancer |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
colchicine amide |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
colchicine sulfonamide |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
tubulin inhibitors |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
docking studies |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
crystal structure |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
PROTACs |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
protein degradation |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
IGF-1R |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
Src |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
protein kinase |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
phenylpyrazolopyrimidine |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
enzyme inhibition |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
molecular simulation |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
androgen receptor |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
prostate cancer |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
enzalutamide |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
apalutamide |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
darolutamide |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
triple-negative breast cancer |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
cytotoxicity |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
chrysin analogues |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
flavonoid |
653 ## - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
anticancer compounds |
700 1# - ADDED ENTRY--PERSONAL NAME |
Personal name |
Chen, Qiao-Hong |
Relator code |
oth |
9 (RLIN) |
1597909 |
856 40 - ELECTRONIC LOCATION AND ACCESS |
Host name |
www.oapen.org |
Uniform Resource Identifier |
<a href="https://mdpi.com/books/pdfview/book/3445">https://mdpi.com/books/pdfview/book/3445</a> |
-- |
0 |
Public note |
DOAB: download the publication |
856 40 - ELECTRONIC LOCATION AND ACCESS |
Host name |
www.oapen.org |
Uniform Resource Identifier |
<a href="https://directory.doabooks.org/handle/20.500.12854/68429">https://directory.doabooks.org/handle/20.500.12854/68429</a> |
-- |
0 |
Public note |
DOAB: description of the publication |