MARC details
| 000 -LEADER |
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| fixed length control field |
02877naaaa2200373uu 4500 |
| 001 - CONTROL NUMBER |
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| control field |
https://directory.doabooks.org/handle/20.500.12854/57181 |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20220714175537.0 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
978-2-88919-605-0 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
9782889196050 |
| 024 7# - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
10.3389/978-2-88919-605-0 |
| Terms of availability |
doi |
| 041 0# - LANGUAGE CODE |
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| Language code of text/sound track or separate title |
English |
| 042 ## - AUTHENTICATION CODE |
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| Authentication code |
dc |
| 100 1# - MAIN ENTRY--PERSONAL NAME |
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| Personal name |
Jean-Luc Vilotte |
| Relator code |
auth |
| 9 (RLIN) |
1594650 |
| 245 10 - TITLE STATEMENT |
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| Title |
Promiscuous functions of the prion protein gene family |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) |
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| Name of publisher, distributor, etc |
Frontiers Media SA |
| Date of publication, distribution, etc |
2015 |
| 300 ## - PHYSICAL DESCRIPTION |
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| Extent |
1 electronic resource (113 p.) |
| 506 0# - RESTRICTIONS ON ACCESS NOTE |
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| Terms governing access |
Open Access |
| Source of term |
star |
| Standardized terminology for access restriction |
Unrestricted online access |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc |
The cellular prion protein PrPC is a ubiquitous GPI-anchored protein. While PrPC has been the focus of intense research for its involvement in a group of neurodegenerative disorders known as transmissible spongiform encephalopathies (TSE), much less attention has been devoted to its physiological function. This notably relates to the lack of obvious abnormalities of mice, goat or cattle lacking PrPC. This apparently normal phenotype in these PrPC-deficient animals however contrasts with the very high degree of conservation of the prion protein gene (Prnp) in mammalian species (over 80%), and the presence of genes with similarities to Prnp in birds, reptiles, amphibians and fish. This high conservation together with its ubiquitous expression, - albeit at highest levels in the brain-, suggest that PrPC has major physiological functions. Dissecting PrPC function is further complicated by the occurrence, in mammals, of two potentially partially redundant homologues, Doppel, and Shadoo. The biological overlaps between members of the prion protein family are still under investigation and much debated. Similarly, although in vitro analyses have suggested various functions for PrPC, notably in cell death and survival processes, some have yielded conflicting results and/or discrepancies with in vivo studies. This Research Topic brings together the accumulated knowledge regarding the biological roles of the prion protein family, from the animal to the molecular scale. |
| 540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE |
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| Terms governing use and reproduction |
Creative Commons |
| -- |
https://creativecommons.org/licenses/by/4.0/ |
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cc |
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https://creativecommons.org/licenses/by/4.0/ |
| 546 ## - LANGUAGE NOTE |
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| Language note |
English |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Stem Cells |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Neuroprotection |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Placenta |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
abeta |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Aging |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Embryonic and Fetal Development |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Cell Adhesion |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Gonads |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Cell signaling |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
prion protein |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Sophie Mouillet-Richard |
| Relator code |
auth |
| 9 (RLIN) |
1594651 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
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| Host name |
www.oapen.org |
| Uniform Resource Identifier |
<a href="http://journal.frontiersin.org/researchtopic/2567/promiscuous-functions-of-the-prion-protein-gene-family">http://journal.frontiersin.org/researchtopic/2567/promiscuous-functions-of-the-prion-protein-gene-family</a> |
| -- |
0 |
| Public note |
DOAB: download the publication |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
|---|
| Host name |
www.oapen.org |
| Uniform Resource Identifier |
<a href="https://directory.doabooks.org/handle/20.500.12854/57181">https://directory.doabooks.org/handle/20.500.12854/57181</a> |
| -- |
0 |
| Public note |
DOAB: description of the publication |
