MARC details
| 000 -LEADER |
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| fixed length control field |
03332naaaa2200361uu 4500 |
| 001 - CONTROL NUMBER |
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| control field |
https://directory.doabooks.org/handle/20.500.12854/55353 |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20220714175109.0 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
978-2-88919-899-3 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
9782889198993 |
| 024 7# - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
10.3389/978-2-88919-899-3 |
| Terms of availability |
doi |
| 041 0# - LANGUAGE CODE |
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| Language code of text/sound track or separate title |
English |
| 042 ## - AUTHENTICATION CODE |
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| Authentication code |
dc |
| 100 1# - MAIN ENTRY--PERSONAL NAME |
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| Personal name |
John T. M. Kennis |
| Relator code |
auth |
| 9 (RLIN) |
1592937 |
| 245 10 - TITLE STATEMENT |
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| Title |
Optogenetic Tools in the Molecular Spotlight |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) |
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| Name of publisher, distributor, etc |
Frontiers Media SA |
| Date of publication, distribution, etc |
2016 |
| 300 ## - PHYSICAL DESCRIPTION |
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| Extent |
1 electronic resource (179 p.) |
| 506 0# - RESTRICTIONS ON ACCESS NOTE |
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| Terms governing access |
Open Access |
| Source of term |
star |
| Standardized terminology for access restriction |
Unrestricted online access |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc |
The rise of optogenetics as a standard technique to non-invasively probe and monitor biological function created an immense interest in the molecular function of photosensory proteins. These photoreceptors are usually protein/pigment complexes that translate light into biological information and have become essential tools in cell biology and neurobiology as their function is genetically encoded and can be conveniently delivered into a given cell. Like for fluorescent proteins that quickly became invaluable as genetically encodable reporters in microscopy and imaging, variants of photosensory proteins with customized sensitivity and functionality are nowadays in high demand. In this ebook we feature reviews and original research on molecular approaches from synthetic biology and molecular spectroscopy to computational molecular modelling that all aspire to elucidate the molecular prerequisites for the photosensory function of the given proteins. The principle property of changing activity of biological function simply by application of light is not only very attractive for cell biology, it also offers unique opportunities for molecular studies as excitation can be controlled with high time precision. Especially in spectroscopy the usually fully reversible photoactivation of photosensory proteins allows researchers to to perform time resolved studies with up to femtosecond resolution. In addition, functional variants can be investigated and quickly screened in common biochemical experiments. The insights that are obtained by the here presented various yet complementary methods will ultimately allow us write the script for a molecular movie from excitation of the protein by a photon to activation of its biological function. Such deep understanding does not only provide unique insights into the dynamics of protein function, it will also ultimately enable us to rationally design novel optogenetic tools to be used in cell biology and therapy. |
| 540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE |
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| Terms governing use and reproduction |
Creative Commons |
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https://creativecommons.org/licenses/by/4.0/ |
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cc |
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https://creativecommons.org/licenses/by/4.0/ |
| 546 ## - LANGUAGE NOTE |
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| Language note |
English |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
photoreceptors |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Opsins |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Photochemistry and photophysics |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
spectroscopy |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
optogenetics |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Phytochrome |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Protein Engineering |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
computational modeling |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Flavins |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Tilo Mathes |
| Relator code |
auth |
| 9 (RLIN) |
1592938 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
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| Host name |
www.oapen.org |
| Uniform Resource Identifier |
<a href="http://journal.frontiersin.org/researchtopic/3172/optogenetic-tools-in-the-molecular-spotlight">http://journal.frontiersin.org/researchtopic/3172/optogenetic-tools-in-the-molecular-spotlight</a> |
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0 |
| Public note |
DOAB: download the publication |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
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| Host name |
www.oapen.org |
| Uniform Resource Identifier |
<a href="https://directory.doabooks.org/handle/20.500.12854/55353">https://directory.doabooks.org/handle/20.500.12854/55353</a> |
| -- |
0 |
| Public note |
DOAB: description of the publication |
