MARC details
| 000 -LEADER |
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| fixed length control field |
03352naaaa2200373uu 4500 |
| 001 - CONTROL NUMBER |
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| control field |
https://directory.doabooks.org/handle/20.500.12854/53258 |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20220714174441.0 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
978-2-88919-739-2 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
9782889197392 |
| 024 7# - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
10.3389/978-2-88919-739-2 |
| Terms of availability |
doi |
| 041 0# - LANGUAGE CODE |
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| Language code of text/sound track or separate title |
English |
| 042 ## - AUTHENTICATION CODE |
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| Authentication code |
dc |
| 100 1# - MAIN ENTRY--PERSONAL NAME |
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| Personal name |
Katja M. Kanninen |
| Relator code |
auth |
| 9 (RLIN) |
1591356 |
| 245 10 - TITLE STATEMENT |
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| Title |
Metals and neurodegeneration: Restoring the balance |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) |
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| Name of publisher, distributor, etc |
Frontiers Media SA |
| Date of publication, distribution, etc |
2016 |
| 300 ## - PHYSICAL DESCRIPTION |
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| Extent |
1 electronic resource (132 p.) |
| 506 0# - RESTRICTIONS ON ACCESS NOTE |
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| Terms governing access |
Open Access |
| Source of term |
star |
| Standardized terminology for access restriction |
Unrestricted online access |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc |
Biometals such as copper, zinc and iron have key biological functions, however, aberrant metabolism can lead to detrimental effects on cell function and survival. These biometals have important roles in the brain, driving cellular respiration, antioxidant activity, intracellular signaling and many additional structural and enzymatic functions. There is now considerable evidence that abnormal biometal homeostasis is a key feature of many neurodegenerative diseases and may have an important role in the onset and progression of disorders such as Alzheimer's, Parkinson's, prion and motor neuron diseases. Recent studies also support biometal roles in a number of less common neurodegenerative disorders. The role of biometals in a growing list of brain disorders is supported by evidence from a wide range of sources including molecular genetics, biochemical studies and biometal imaging. These studies have spurred a growing interest in understanding the role of biometals in brain function and disease as well as the development of therapeutic approaches that may be able to restore the altered biometal chemistry of the brain. These approaches range from genetic manipulation of biometal transport to chelation of excess metals or delivery of metals where levels are deficient. A number of these approaches are offering promising results in cellular and animal models of neurodegeneration with successful translation to pre-clinical and clinical trials. At a time of aging populations and slow progress in development of neurotherapeutics to treat age-related neurodegenerative diseases, there is now a critical need to further our understanding of biometals in neurodegeneration. This issue covers a broad range of topics related to biometals and their role in neurodegeneration. It is hoped that this will inspire greater discussion and exchange of ideas in this crucial area of research and lead to positive outcomes for sufferers of these neurodegenerative diseases. |
| 540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE |
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| Terms governing use and reproduction |
Creative Commons |
| -- |
https://creativecommons.org/licenses/by/4.0/ |
| -- |
cc |
| -- |
https://creativecommons.org/licenses/by/4.0/ |
| 546 ## - LANGUAGE NOTE |
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| Language note |
English |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Brain |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
neurodegenerative disease |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Neurons |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Metals |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Iron |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Copper |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Alzheimer's disease |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Zinc |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Manganese |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Anthony R. White |
| Relator code |
auth |
| 9 (RLIN) |
1591357 |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Peter J. Crouch |
| Relator code |
auth |
| 9 (RLIN) |
1591358 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
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| Host name |
www.oapen.org |
| Uniform Resource Identifier |
<a href="http://journal.frontiersin.org/researchtopic/820/metals-and-neurodegeneration-restoring-the-balance">http://journal.frontiersin.org/researchtopic/820/metals-and-neurodegeneration-restoring-the-balance</a> |
| -- |
0 |
| Public note |
DOAB: download the publication |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
|---|
| Host name |
www.oapen.org |
| Uniform Resource Identifier |
<a href="https://directory.doabooks.org/handle/20.500.12854/53258">https://directory.doabooks.org/handle/20.500.12854/53258</a> |
| -- |
0 |
| Public note |
DOAB: description of the publication |
