MARC details
| 000 -LEADER |
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| fixed length control field |
05247naaaa2201237uu 4500 |
| 001 - CONTROL NUMBER |
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| control field |
https://directory.doabooks.org/handle/20.500.12854/78735 |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20220714163648.0 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
books978-3-0365-2856-4 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
9783036528564 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
9783036528571 |
| 024 7# - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
10.3390/books978-3-0365-2856-4 |
| Terms of availability |
doi |
| 041 0# - LANGUAGE CODE |
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| Language code of text/sound track or separate title |
English |
| 042 ## - AUTHENTICATION CODE |
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| Authentication code |
dc |
| 072 #7 - SUBJECT CATEGORY CODE |
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| Subject category code |
GP |
| Source |
bicssc |
| 072 #7 - SUBJECT CATEGORY CODE |
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| Subject category code |
PS |
| Source |
bicssc |
| 100 1# - MAIN ENTRY--PERSONAL NAME |
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| Personal name |
De Falco, Valentina |
| Relator code |
edt |
| 9 (RLIN) |
1577296 |
| 245 10 - TITLE STATEMENT |
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| Title |
Targeted Cancer Therapy and Mechanisms of Resistance |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) |
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| Place of publication, distribution, etc |
Basel |
| Name of publisher, distributor, etc |
MDPI - Multidisciplinary Digital Publishing Institute |
| Date of publication, distribution, etc |
2022 |
| 300 ## - PHYSICAL DESCRIPTION |
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| Extent |
1 electronic resource (280 p.) |
| 506 0# - RESTRICTIONS ON ACCESS NOTE |
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| Terms governing access |
Open Access |
| Source of term |
star |
| Standardized terminology for access restriction |
Unrestricted online access |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc |
Tumor cells commonly exhibit dependence on a single activated oncogenic pathway or protein to maintain their malignant proliferation and survival, a phenomenon called "oncogene addiction". According to this concept, protein kinases have been identified as promising molecular targets for cancer therapy. There are several possibilities for targeting these proteins in cancer, including monoclonal antibodies, compounds able to favor the proteolytic degradation of the kinase, small-molecule protein kinase inhibitors (PKIs). Moreover, new anticancer treatments have increasingly been developed focusing on tumor suppressor genes and RNA interference. Despite promising results in cancer treatment with targeted cancer drugs, clinical experience has shown that only a fraction of patients respond to targeted therapies, even if their tumor expresses the altered target. This is known as primary resistance. Otherwise, secondary or acquired resistance to the treatment arises, almost invariably, when tumors are treated with cancer drugs. We set out to select some studies containing emerging developments on the subject. In essence, this collection aims to highlight some recent findings regarding resistance mechanisms and reviews of molecular targeting and resistance with 14 contributions, including 10 original research papers and 4 reviews. Aspects relating to solid cancers, such as breast, ovary, colon, and blood cancers such as leukemia, and the identification of resistance mechanisms and new molecular targets, help to create the basis for the preclinical and clinical development of more effective next-generation drugs. |
| 540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE |
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| Terms governing use and reproduction |
Creative Commons |
| -- |
https://creativecommons.org/licenses/by/4.0/ |
| -- |
cc |
| -- |
https://creativecommons.org/licenses/by/4.0/ |
| 546 ## - LANGUAGE NOTE |
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| Language note |
English |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Research & information: general |
| Source of heading or term |
bicssc |
| 9 (RLIN) |
928234 |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Biology, life sciences |
| Source of heading or term |
bicssc |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
3D spheroids |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
photothermy |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
gold nanoparticles |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
doxorubicin resistance |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
colorectal cancer |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
cellular prion protein |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
PrPC |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
PRNP |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
cancer |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
cancer stem cell |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
targeted cancer therapy |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
brain metastases |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
treatment |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
non-small cell lung carcinoma |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
EGFR |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
ALK |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
immunotherapy |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
HDAC6 |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
bortezomib-resistance |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
HDAC6-selective inhibitor |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
bortezomib |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
carfilzomib |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
multiple myeloma |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
LMP2 |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
combination therapy |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
colorectal cancer cells |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
drug resistance |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
5-Fluorouracil |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
thymidylate synthase |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
exome sequencing |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
CD47 |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
immune activation |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
pro-tumoral macrophages |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
breast cancer |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
polo-like kinase 1 (PLK1) |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
pyrazole |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
quantitative structure-activity relationship |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
hybridization |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
ovarian cancer |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
cisplatin |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
cisplatin resistance |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
PARPi |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
niraparib |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Twist |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
lethality |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
AF4 |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
cell culture |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
FGFR2 |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
HOXA9 |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
MLL-AF4 |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
nucleus |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
target therapy |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
t(4 |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
11) leukemia |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
radiation-resistant |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
cell death |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
ERK |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
EMT |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
cancer stem cells (CSCs) |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
PD98059 |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
PARP inhibitors |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
PARP inhibitor resistance |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
signal transduction networks |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
pathways |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
event-free survival |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
biomarkers |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
WNT pathway |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
targeted therapy |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Wee1 kinase |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
cell cycle |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
tumor resistance |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
lenvatinib |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
sorafenib-resistant |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
hepatocellular carcinoma |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
FGFR4 |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
autophagy |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
microRNA |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
De Falco, Valentina |
| Relator code |
oth |
| 9 (RLIN) |
1577296 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
|---|
| Host name |
www.oapen.org |
| Uniform Resource Identifier |
<a href="https://mdpi.com/books/pdfview/book/4826">https://mdpi.com/books/pdfview/book/4826</a> |
| -- |
0 |
| Public note |
DOAB: download the publication |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
|---|
| Host name |
www.oapen.org |
| Uniform Resource Identifier |
<a href="https://directory.doabooks.org/handle/20.500.12854/78735">https://directory.doabooks.org/handle/20.500.12854/78735</a> |
| -- |
0 |
| Public note |
DOAB: description of the publication |
