MARC details
| 000 -LEADER |
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| fixed length control field |
03196naaaa2200337uu 4500 |
| 001 - CONTROL NUMBER |
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| control field |
https://directory.doabooks.org/handle/20.500.12854/42858 |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20220714163336.0 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
978-2-88945-455-6 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
9782889454556 |
| 024 7# - OTHER STANDARD IDENTIFIER |
|---|
| Standard number or code |
10.3389/978-2-88945-455-6 |
| Terms of availability |
doi |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
English |
| 042 ## - AUTHENTICATION CODE |
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| Authentication code |
dc |
| 100 1# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Abhay Satoskar |
| Relator code |
auth |
| 9 (RLIN) |
1576131 |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Cell Signaling in Host-Pathogen Interactions: The Host Point of View |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) |
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| Name of publisher, distributor, etc |
Frontiers Media SA |
| Date of publication, distribution, etc |
2018 |
| 300 ## - PHYSICAL DESCRIPTION |
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| Extent |
1 electronic resource (414 p.) |
| 506 0# - RESTRICTIONS ON ACCESS NOTE |
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| Terms governing access |
Open Access |
| Source of term |
star |
| Standardized terminology for access restriction |
Unrestricted online access |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc |
The ability of pathogens, such as parasites, bacteria, fungi and viruses to invade, persist and adapt in both invertebrate and vertebrate hosts is multifactorial and depends on both pathogen and host fitness. Communication between a pathogen and its host relies on a wide and dynamic array of molecular interactions. Through this constant communication most pathogens evolved to be relatively benign, whereas killing of its host by a pathogen represents a failure to adapt. Pathogens are lethal to their host when their interaction has not been long enough for adaptation. Evolution has selected conserved immune receptors that recognize signature patterns of pathogens as non-self elements and initiate host innate responses aimed at eradicating infection. Conversely, pathogens evolved mechanisms to evade immune recognition and subvert cytokine secretion in order to survive, replicate and cause disease. The cell signaling machinery is a critical component of the immune system that relays information from the receptors to the nucleus where transcription of key immune genes is activated. Host cells have developed signal transduction systems to maintain homeostasis with pathogens. Most cellular processes and cell signaling pathways are tightly regulated by protein phosphorylation in which protein kinases are key protagonists. Pathogens have developed multiple mechanisms to subvert important signal transduction pathways such as the mitogen activated protein kinase (MAPK) and the nuclear factor kB (NF-kB) pathways. Pathogens also secrete effectors that manipulate actin cytoskeleton and its regulators, hijack cell cycle machinery and alter vesicular trafficking. This research topic focuses on the cellular signaling mechanisms that are essential for host immunity and their subversion by pathogens. |
| 540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE |
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| Terms governing use and reproduction |
Creative Commons |
| -- |
https://creativecommons.org/licenses/by/4.0/ |
| -- |
cc |
| -- |
https://creativecommons.org/licenses/by/4.0/ |
| 546 ## - LANGUAGE NOTE |
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| Language note |
English |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
host-pathogen interaction |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Protein Kinases |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
innate immunity |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
immune signaling |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
host response to microorganisms |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Cell signaling |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Diana Bahia |
| Relator code |
auth |
| 9 (RLIN) |
1576132 |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Olivier Dussurget |
| Relator code |
auth |
| 9 (RLIN) |
1576133 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
|---|
| Host name |
www.oapen.org |
| Uniform Resource Identifier |
<a href="https://www.frontiersin.org/research-topics/3518/cell-signaling-in-host-pathogen-interactions-the-host-point-of-view">https://www.frontiersin.org/research-topics/3518/cell-signaling-in-host-pathogen-interactions-the-host-point-of-view</a> |
| -- |
0 |
| Public note |
DOAB: download the publication |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
|---|
| Host name |
www.oapen.org |
| Uniform Resource Identifier |
<a href="https://directory.doabooks.org/handle/20.500.12854/42858">https://directory.doabooks.org/handle/20.500.12854/42858</a> |
| -- |
0 |
| Public note |
DOAB: description of the publication |
