MARC details
| 000 -LEADER |
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| fixed length control field |
03080naaaa2200325uu 4500 |
| 001 - CONTROL NUMBER |
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| control field |
https://directory.doabooks.org/handle/20.500.12854/49982 |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20220714163321.0 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
978-2-88945-618-5 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
9782889456185 |
| 024 7# - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
10.3389/978-2-88945-618-5 |
| Terms of availability |
doi |
| 041 0# - LANGUAGE CODE |
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| Language code of text/sound track or separate title |
English |
| 042 ## - AUTHENTICATION CODE |
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| Authentication code |
dc |
| 100 1# - MAIN ENTRY--PERSONAL NAME |
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| Personal name |
Britta Siegmund |
| Relator code |
auth |
| 9 (RLIN) |
1576024 |
| 245 10 - TITLE STATEMENT |
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| Title |
Immune-Epithelial Crosstalk in Inflammatory Bowel Diseases and Mucosal Wound Healing |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) |
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| Name of publisher, distributor, etc |
Frontiers Media SA |
| Date of publication, distribution, etc |
2018 |
| 300 ## - PHYSICAL DESCRIPTION |
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| Extent |
1 electronic resource (159 p.) |
| 506 0# - RESTRICTIONS ON ACCESS NOTE |
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| Terms governing access |
Open Access |
| Source of term |
star |
| Standardized terminology for access restriction |
Unrestricted online access |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc |
80% of the bodies' immune cells are harbored within the intestine. They are only separated from 1014 microorganisms by a single layer of intestinal epithelial cells and a secreted superficial mucus layer. Therefore, the intestinal epithelial surface represents a main frontier in host defense. Providing an intact mucosal barrier is vital for the host to limit bacterial entry and spread to the circulation. This specialized localization requires dynamic responses of intestinal epithelial cells to both pathogen- and immune-derived signals. Moreover, emergency barriers are needed in the setting of epithelial damage, which allow provisional microbial control and a timely restitution of mucosal integrity. Epithelial cells constantly interact with subjacent immune cells and fibroblasts, actively directing the immune response and also shaping the luminal microbiota. Epithelial dysfunction has been appreciated in recent years as a driving element in the pathogenesis of Inflammatory Bowel Diseases (IBD). Additionally, primary immune deficiencies may manifest in the form of chronic intestinal inflammation mimicking features of IBD. Recent advances in the techniques of epithelial cell culture and the discovery of new immune cell types and cellular properties have tremendously advanced the understanding in this interesting field of research. In this research topic, we want to focus on the complex interaction of intestinal epithelial cells, luminal flora and adjacent immune cells and invite manuscripts which highlight the dynamic responses of both epithelium and immune cells under steady-state or inflammatory conditions, and envision how this may be translated to the benefit of patient-care. |
| 540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE |
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| Terms governing use and reproduction |
Creative Commons |
| -- |
https://creativecommons.org/licenses/by/4.0/ |
| -- |
cc |
| -- |
https://creativecommons.org/licenses/by/4.0/ |
| 546 ## - LANGUAGE NOTE |
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| Language note |
English |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
lymphocytes |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
inflammatory bowel diseases |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
immune system |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
intestinal epithelium |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
mucosal immunity |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Moritz Leppkes |
| Relator code |
auth |
| 9 (RLIN) |
1576025 |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Christoph Becker |
| Relator code |
auth |
| 9 (RLIN) |
1576026 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
|---|
| Host name |
www.oapen.org |
| Uniform Resource Identifier |
<a href="https://www.frontiersin.org/research-topics/5608/immune-epithelial-crosstalk-in-inflammatory-bowel-diseases-and-mucosal-wound-healing">https://www.frontiersin.org/research-topics/5608/immune-epithelial-crosstalk-in-inflammatory-bowel-diseases-and-mucosal-wound-healing</a> |
| -- |
0 |
| Public note |
DOAB: download the publication |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
|---|
| Host name |
www.oapen.org |
| Uniform Resource Identifier |
<a href="https://directory.doabooks.org/handle/20.500.12854/49982">https://directory.doabooks.org/handle/20.500.12854/49982</a> |
| -- |
0 |
| Public note |
DOAB: description of the publication |
