In-Cell NMR Spectroscopy: Biomolecular Structure and Function
Burz, David S.
In-Cell NMR Spectroscopy: Biomolecular Structure and Function - MDPI - Multidisciplinary Digital Publishing Institute 2020 - 1 electronic resource (152 p.)
Open Access
This Special Issue examines state-of-the-art in-cell NMR spectroscopy as it relates to biological systems of increasing complexity. The compendia of research and recent innovations from prominent laboratories in the field of solid state and solution in-cell NMR spectroscopy, metabolomics and technology development are presented. The work establishes in-cell NMR spectroscopy as the premier method for determining the structures and interaction capabilities of biological molecules at high resolution within the delicately intricate interior of living cells, and the means of utilizing cells as living laboratories to directly assess the effects of exogenous and endogenous stimuli on cell physiology.]
Creative Commons
English
books978-3-03928-255-5 9783039282555 9783039282548
10.3390/books978-3-03928-255-5 doi
protein NMR time-resolved NMR Ribosome structural calculation 4 crystalline and amorphous starch in-cell NMR protein dynamics DNP protein modification Tau spectrum reconstruction 3 mRNA Thioredoxin protein structure protein interactions drug discovery protein structure determination 1 review enzyme activity MARK2 phosphorylation post-translational modifications Dihydrofolate reductase mammalian cells target engagement non-uniform sampling 2 paramagnetic effects protein structure-function cross-correlated relaxation structure function rRNA 2D INADEQUATE lipid membrane Thymidylate synthase whole cell NMR enzyme kinetics magic-angle spinning live cell solid-state NMR Adenylate kinase DNA in-situ NMR antimicrobial peptide NMR spectroscopy intrinsically disordered proteins
In-Cell NMR Spectroscopy: Biomolecular Structure and Function - MDPI - Multidisciplinary Digital Publishing Institute 2020 - 1 electronic resource (152 p.)
Open Access
This Special Issue examines state-of-the-art in-cell NMR spectroscopy as it relates to biological systems of increasing complexity. The compendia of research and recent innovations from prominent laboratories in the field of solid state and solution in-cell NMR spectroscopy, metabolomics and technology development are presented. The work establishes in-cell NMR spectroscopy as the premier method for determining the structures and interaction capabilities of biological molecules at high resolution within the delicately intricate interior of living cells, and the means of utilizing cells as living laboratories to directly assess the effects of exogenous and endogenous stimuli on cell physiology.]
Creative Commons
English
books978-3-03928-255-5 9783039282555 9783039282548
10.3390/books978-3-03928-255-5 doi
protein NMR time-resolved NMR Ribosome structural calculation 4 crystalline and amorphous starch in-cell NMR protein dynamics DNP protein modification Tau spectrum reconstruction 3 mRNA Thioredoxin protein structure protein interactions drug discovery protein structure determination 1 review enzyme activity MARK2 phosphorylation post-translational modifications Dihydrofolate reductase mammalian cells target engagement non-uniform sampling 2 paramagnetic effects protein structure-function cross-correlated relaxation structure function rRNA 2D INADEQUATE lipid membrane Thymidylate synthase whole cell NMR enzyme kinetics magic-angle spinning live cell solid-state NMR Adenylate kinase DNA in-situ NMR antimicrobial peptide NMR spectroscopy intrinsically disordered proteins