Genome Mining and Marine Microbial Natural Products
Hong, Kui
Genome Mining and Marine Microbial Natural Products - MDPI - Multidisciplinary Digital Publishing Institute 2020 - 1 electronic resource (202 p.)
Open Access
Two review papers, eight research articles, and one brief report were published in this Special Issue. They showed the rich resources that are present within the genomes of marine microorganisms and discussed the use of recently developed tools and technologies to exploit this genetic richness. Examples include the rational supply of precursors according to the relevant biosynthetic pathway and stress driven discovery together with the use of histone deacetylase inhibitors to facilitate the discovery of new bioactive molecules with potential biopharmaceutical applications. We believe that the content of this Special Issue reflects the current state-of-the-art research in this area and highlights the interesting strategies that are being employed to uncover increasing numbers of exciting novel compounds for drug discovery from marine genetic resources.
Creative Commons
English
books978-3-03928-091-9 9783039280919 9783039280902
10.3390/books978-3-03928-091-9 doi
antibacterial activity polyketide synthase halo-extremophyles antibacterial gene cluster Penicillium chrysogenum bacillomycin secondary metabolites drug discovery biosynthesis polycyclic tetramate macrolactams actinobacteria biosynthetic gene clusters phylotype comparative genomics IclR family regulator polyketide antibiotics antifungal fatty acid amide Antarctica marine microorganisms NdgRyo nonribosomal peptides Marisediminicola genome mining antimicrobial sponge Stachybotrys carotenoid marine archaea haloenzymes natural products Streptomyces sp. SCSIO 40010 16S rRNA metagenomics ecotype medicinal chemistry cytotoxicity marine natural products (MNPs) Streptomyces marine Bacillus antimicrobial activity amino compound bacillibactin meroterpenoid fibrinolytic activity metal stress technique isoindolinone biosynthesis Streptomyces pratensis histone-deacetylase inhibitor marine natural product Odiel marshlands
Genome Mining and Marine Microbial Natural Products - MDPI - Multidisciplinary Digital Publishing Institute 2020 - 1 electronic resource (202 p.)
Open Access
Two review papers, eight research articles, and one brief report were published in this Special Issue. They showed the rich resources that are present within the genomes of marine microorganisms and discussed the use of recently developed tools and technologies to exploit this genetic richness. Examples include the rational supply of precursors according to the relevant biosynthetic pathway and stress driven discovery together with the use of histone deacetylase inhibitors to facilitate the discovery of new bioactive molecules with potential biopharmaceutical applications. We believe that the content of this Special Issue reflects the current state-of-the-art research in this area and highlights the interesting strategies that are being employed to uncover increasing numbers of exciting novel compounds for drug discovery from marine genetic resources.
Creative Commons
English
books978-3-03928-091-9 9783039280919 9783039280902
10.3390/books978-3-03928-091-9 doi
antibacterial activity polyketide synthase halo-extremophyles antibacterial gene cluster Penicillium chrysogenum bacillomycin secondary metabolites drug discovery biosynthesis polycyclic tetramate macrolactams actinobacteria biosynthetic gene clusters phylotype comparative genomics IclR family regulator polyketide antibiotics antifungal fatty acid amide Antarctica marine microorganisms NdgRyo nonribosomal peptides Marisediminicola genome mining antimicrobial sponge Stachybotrys carotenoid marine archaea haloenzymes natural products Streptomyces sp. SCSIO 40010 16S rRNA metagenomics ecotype medicinal chemistry cytotoxicity marine natural products (MNPs) Streptomyces marine Bacillus antimicrobial activity amino compound bacillibactin meroterpenoid fibrinolytic activity metal stress technique isoindolinone biosynthesis Streptomyces pratensis histone-deacetylase inhibitor marine natural product Odiel marshlands