Dual Specificity Phosphatases: From Molecular Mechanisms to Biological Function
Pulido, Rafael
Dual Specificity Phosphatases: From Molecular Mechanisms to Biological Function - MDPI - Multidisciplinary Digital Publishing Institute 2019 - 1 electronic resource (240 p.)
Open Access
Dual specificity phosphatases (DUSPs) constitute a heterogeneous group of protein tyrosine phosphatases with the ability to dephosphorylate Ser/Thr and Tyr residues from proteins, as well as from other non-proteinaceous substrates including signaling lipids. DUSPs include, among others, MAP kinase (MAPK) phosphatases (MKPs) and small-size atypical DUSPs. MKPs are enzymes specialized in regulating the activity and subcellular location of MAPKs, whereas the function of small-size atypical DUSPs seems to be more diverse. DUSPs have emerged as key players in the regulation of cell growth, differentiation, stress response, and apoptosis. DUSPs regulate essential physiological processes, including immunity, neurobiology and metabolic homeostasis, and have been implicated in tumorigenesis, pathological inflammation and metabolic disorders. Accordingly, alterations in the expression or function of MKPs and small-size atypical DUSPs have consequences essential to human disease, making these enzymes potential biological markers and therapeutic targets. This Special Issue covers recent advances in the molecular mechanisms and biological functions of MKPs and small-size atypical DUSPs, and their relevance in human disease.
Creative Commons
English
books978-3-03921-689-5 9783039216895 9783039216888
10.3390/books978-3-03921-689-5 doi
hematopoietic cells DEPArray n/a neuroblastoma liver steatosis MAPK phosphatase DUSP-4 granule neurons neuronal differentiation DUSP10 cytokines MAPKs single cell analysis macrophage asthma E. coli infection MAPK Cpp1 nucleotide receptors atypical DUSP RSV Pmp1 cannabinoids astrocytes sepsis influenza signaling triple-negative breast cancer (TNBC) differentiation HDAC6 (histone deacetylase isoform 6) atypical dual-specificity phosphatases microtubules respiratory viruses MK-STYX (MAPK (mitogen-activated protein kinase) phosphoserine/threonine/tyrosine-binding protein) dual-specificity phosphatase Msg5 TLR signaling mitogen-activated protein kinase fungal MKPs macrophages MAP Kinase Phosphatase-2 inflammation Sdp1 circulating tumor cells (CTCs) MAP kinases MAP kinase phosphatases P2X7 proliferation BDNF P2Y13 T cell hypertriglyceridemia integrated omics analysis post-translational modification rhinovirus protein stability ubiquitination dual-specificity phosphatases Mkp-1 cancer brain metastasis HER2 COPD pseudophosphatase
Dual Specificity Phosphatases: From Molecular Mechanisms to Biological Function - MDPI - Multidisciplinary Digital Publishing Institute 2019 - 1 electronic resource (240 p.)
Open Access
Dual specificity phosphatases (DUSPs) constitute a heterogeneous group of protein tyrosine phosphatases with the ability to dephosphorylate Ser/Thr and Tyr residues from proteins, as well as from other non-proteinaceous substrates including signaling lipids. DUSPs include, among others, MAP kinase (MAPK) phosphatases (MKPs) and small-size atypical DUSPs. MKPs are enzymes specialized in regulating the activity and subcellular location of MAPKs, whereas the function of small-size atypical DUSPs seems to be more diverse. DUSPs have emerged as key players in the regulation of cell growth, differentiation, stress response, and apoptosis. DUSPs regulate essential physiological processes, including immunity, neurobiology and metabolic homeostasis, and have been implicated in tumorigenesis, pathological inflammation and metabolic disorders. Accordingly, alterations in the expression or function of MKPs and small-size atypical DUSPs have consequences essential to human disease, making these enzymes potential biological markers and therapeutic targets. This Special Issue covers recent advances in the molecular mechanisms and biological functions of MKPs and small-size atypical DUSPs, and their relevance in human disease.
Creative Commons
English
books978-3-03921-689-5 9783039216895 9783039216888
10.3390/books978-3-03921-689-5 doi
hematopoietic cells DEPArray n/a neuroblastoma liver steatosis MAPK phosphatase DUSP-4 granule neurons neuronal differentiation DUSP10 cytokines MAPKs single cell analysis macrophage asthma E. coli infection MAPK Cpp1 nucleotide receptors atypical DUSP RSV Pmp1 cannabinoids astrocytes sepsis influenza signaling triple-negative breast cancer (TNBC) differentiation HDAC6 (histone deacetylase isoform 6) atypical dual-specificity phosphatases microtubules respiratory viruses MK-STYX (MAPK (mitogen-activated protein kinase) phosphoserine/threonine/tyrosine-binding protein) dual-specificity phosphatase Msg5 TLR signaling mitogen-activated protein kinase fungal MKPs macrophages MAP Kinase Phosphatase-2 inflammation Sdp1 circulating tumor cells (CTCs) MAP kinases MAP kinase phosphatases P2X7 proliferation BDNF P2Y13 T cell hypertriglyceridemia integrated omics analysis post-translational modification rhinovirus protein stability ubiquitination dual-specificity phosphatases Mkp-1 cancer brain metastasis HER2 COPD pseudophosphatase