MERS-CoV
Du, Lanying
MERS-CoV - MDPI - Multidisciplinary Digital Publishing Institute 2019 - 1 electronic resource (274 p.)
Open Access
Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging zoonotic coronavirus. First identified in 2012, MERS-CoV has caused over 2460 infections and a fatality rate of about 35% in humans. Similar to severe acute respiratory syndrome coronavirus (SARS-CoV), MERS-CoV likely originated from bats; however, different from SARS-CoV, which potentially utilized palm civets as its intermediate hosts, MERS-CoV likely transmits to humans through dromedary camels. Animal models, such as humanized mice and nonhuman primates, have been developed for studying MERS-CoV infection. Currently, there are no vaccines and therapeutics approved for the prevention and treatment of MERS-CoV infection, although a number of them have been developed preclinically or tested clinically. This book covers one editorial and 16 articles (including seven review articles and nine original research papers) written by researchers working in the field of MERS-CoV. It describes the following three main aspects: (1) MERS-CoV epidemiology, transmission, and pathogenesis; (2) current progress on MERS-CoV animal models, vaccines, and therapeutics; and (3) challenges and future prospects for MERS-CoV research. Overall, this book will help researchers in the MERS-CoV field to further advance their work on the virus. It also has important implications for other coronaviruses as well as viruses outside the coronavirus family with pandemic potentials.
Creative Commons
English
books978-3-03921-851-6 9783039218509 9783039218516
10.3390/books978-3-03921-851-6 doi
cell-cell fusion hDPP4 n/a therapeutics animal models HCoV-229E Drivers camels rabbits SARS-CoV MERS-CoV MVA vaccine transmission RBD MERS-CoV nucleocapsid protein complement animal model pseudotyped virus combination MERS-coronavirus peptide mouse model spike protein receptor-binding domain prevention and treatment coronaviruses coronavirus spike glycoprotein therapeutic antibodies vaccine platforms mutation severe acute respiratory syndrome coronavirus pathogenesis fusion inhibitor Coronavirus murine CD8+ T cell epitope lipidomics authentic virus correlates of immunity vaccines neutralizing monoclonal antibodies Middle East respiratory syndrome coronavirus small-molecule inhibitor Middle East Respiratory Syndrome Virus DPP4 pyroptosis cross-neutralization inflammation Qatar spike proteins One Health HKU4 nanobodies mechanism of action neutralizing antibody host factors UHPLC-MS
MERS-CoV - MDPI - Multidisciplinary Digital Publishing Institute 2019 - 1 electronic resource (274 p.)
Open Access
Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging zoonotic coronavirus. First identified in 2012, MERS-CoV has caused over 2460 infections and a fatality rate of about 35% in humans. Similar to severe acute respiratory syndrome coronavirus (SARS-CoV), MERS-CoV likely originated from bats; however, different from SARS-CoV, which potentially utilized palm civets as its intermediate hosts, MERS-CoV likely transmits to humans through dromedary camels. Animal models, such as humanized mice and nonhuman primates, have been developed for studying MERS-CoV infection. Currently, there are no vaccines and therapeutics approved for the prevention and treatment of MERS-CoV infection, although a number of them have been developed preclinically or tested clinically. This book covers one editorial and 16 articles (including seven review articles and nine original research papers) written by researchers working in the field of MERS-CoV. It describes the following three main aspects: (1) MERS-CoV epidemiology, transmission, and pathogenesis; (2) current progress on MERS-CoV animal models, vaccines, and therapeutics; and (3) challenges and future prospects for MERS-CoV research. Overall, this book will help researchers in the MERS-CoV field to further advance their work on the virus. It also has important implications for other coronaviruses as well as viruses outside the coronavirus family with pandemic potentials.
Creative Commons
English
books978-3-03921-851-6 9783039218509 9783039218516
10.3390/books978-3-03921-851-6 doi
cell-cell fusion hDPP4 n/a therapeutics animal models HCoV-229E Drivers camels rabbits SARS-CoV MERS-CoV MVA vaccine transmission RBD MERS-CoV nucleocapsid protein complement animal model pseudotyped virus combination MERS-coronavirus peptide mouse model spike protein receptor-binding domain prevention and treatment coronaviruses coronavirus spike glycoprotein therapeutic antibodies vaccine platforms mutation severe acute respiratory syndrome coronavirus pathogenesis fusion inhibitor Coronavirus murine CD8+ T cell epitope lipidomics authentic virus correlates of immunity vaccines neutralizing monoclonal antibodies Middle East respiratory syndrome coronavirus small-molecule inhibitor Middle East Respiratory Syndrome Virus DPP4 pyroptosis cross-neutralization inflammation Qatar spike proteins One Health HKU4 nanobodies mechanism of action neutralizing antibody host factors UHPLC-MS