PLGA Based Drug Carrier and Pharmaceutical Applications
Pereira, Maria Carmo
PLGA Based Drug Carrier and Pharmaceutical Applications - Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2021 - 1 electronic resource (328 p.)
Open Access
Poly(lactic-co-glycolic acid) (PLGA) is one of the most successful polymers used for producing therapeutic devices, such as drug carriers (DC). PLGA is one of the few polymers that the Food and Drug Administration (FDA) has approved for human administration due to its biocompatibility and biodegradability. In recent years, DC produced with PLGA has gained enormous attention for its versatility in transporting different type of drugs, e.g., hydrophilic or hydrophobic small molecules, or macromolecules with a controlled drug release without modifying the physiochemical properties of the drugs. These drug delivery systems have the possibility/potential to modify their surface properties with functional groups, peptides, or other coatings to improve the interactions with biological materials. Furthermore, they present the possibility to be conjugated with specific target molecules to reach specific tissues or cells. They are also used for different therapeutic applications, such as in vaccinations, cancer treatment, neurological disorder treatment, and as anti-inflammatory agents. This book aims to focus on the recent progress of PLGA as a drug carrier and their new pharmaceutical applications.
Creative Commons
English
books978-3-0365-0221-2 9783036502205 9783036502212
10.3390/books978-3-0365-0221-2 doi
Medicine
PLGA nanoscaled drug delivery LED cancer serum stability reactive oxygen species cellular uptake terahertz spectroscopy microspheres drug delivery formulation development molecular mobility vitamin E tocopherol PLA core-shell nanoparticles controlled drug release BMP-2 PLGA nanoparticles Pluronic F68 oxaliplatin hydrogel intra-abdominal anti-adhesion barrier colorectal cancer experimental design fractional factorial design O6-methylguanine DNA methyltransferase (MGMT) protein glioblastoma multiforme smart nanocarriers folic acid verteporfin cisplatin SKOV-3 cells CHO-K1 cells electroporation theranostic cargo double emulsion approach NSAIDs polymeric film topical drug delivery trolamine salicylate triamcinolone acetonide microcrystal PLGA microsphere local delivery spray-drying technique intra-articular injection joint retention systemic exposure gadolinium drug release polymeric nanocarrier sorafenib theranostic nanoparticles PLGA-PEG nanoparticles platelet activation aggregation binding uptake tissue engineering Huntington's disease siRNA microcarriers mesenchymal stromal cells drug delivery systems microfluidics microparticles BMP-2-microspheres hydrogel system 17-βestradiol release bone regeneration osteoporosis poly-lactide-co-glycolide polylactic acid alginate ophthalmic drug delivery dexamethasone PLGA-NPs nanomedicine gastrointestinal tract paclitaxel in vivo imaging controlled release risperidone microcapsules oleogels electron microscopy three-dimensional X-ray imaging nano-CT biodegradable polymers hydroxy-stearic acid PLGA nanocapsules magnetic resonance imaging photoluminescence magnetic targeting multimodal imaging theranostics silicon microsphere n/a
PLGA Based Drug Carrier and Pharmaceutical Applications - Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2021 - 1 electronic resource (328 p.)
Open Access
Poly(lactic-co-glycolic acid) (PLGA) is one of the most successful polymers used for producing therapeutic devices, such as drug carriers (DC). PLGA is one of the few polymers that the Food and Drug Administration (FDA) has approved for human administration due to its biocompatibility and biodegradability. In recent years, DC produced with PLGA has gained enormous attention for its versatility in transporting different type of drugs, e.g., hydrophilic or hydrophobic small molecules, or macromolecules with a controlled drug release without modifying the physiochemical properties of the drugs. These drug delivery systems have the possibility/potential to modify their surface properties with functional groups, peptides, or other coatings to improve the interactions with biological materials. Furthermore, they present the possibility to be conjugated with specific target molecules to reach specific tissues or cells. They are also used for different therapeutic applications, such as in vaccinations, cancer treatment, neurological disorder treatment, and as anti-inflammatory agents. This book aims to focus on the recent progress of PLGA as a drug carrier and their new pharmaceutical applications.
Creative Commons
English
books978-3-0365-0221-2 9783036502205 9783036502212
10.3390/books978-3-0365-0221-2 doi
Medicine
PLGA nanoscaled drug delivery LED cancer serum stability reactive oxygen species cellular uptake terahertz spectroscopy microspheres drug delivery formulation development molecular mobility vitamin E tocopherol PLA core-shell nanoparticles controlled drug release BMP-2 PLGA nanoparticles Pluronic F68 oxaliplatin hydrogel intra-abdominal anti-adhesion barrier colorectal cancer experimental design fractional factorial design O6-methylguanine DNA methyltransferase (MGMT) protein glioblastoma multiforme smart nanocarriers folic acid verteporfin cisplatin SKOV-3 cells CHO-K1 cells electroporation theranostic cargo double emulsion approach NSAIDs polymeric film topical drug delivery trolamine salicylate triamcinolone acetonide microcrystal PLGA microsphere local delivery spray-drying technique intra-articular injection joint retention systemic exposure gadolinium drug release polymeric nanocarrier sorafenib theranostic nanoparticles PLGA-PEG nanoparticles platelet activation aggregation binding uptake tissue engineering Huntington's disease siRNA microcarriers mesenchymal stromal cells drug delivery systems microfluidics microparticles BMP-2-microspheres hydrogel system 17-βestradiol release bone regeneration osteoporosis poly-lactide-co-glycolide polylactic acid alginate ophthalmic drug delivery dexamethasone PLGA-NPs nanomedicine gastrointestinal tract paclitaxel in vivo imaging controlled release risperidone microcapsules oleogels electron microscopy three-dimensional X-ray imaging nano-CT biodegradable polymers hydroxy-stearic acid PLGA nanocapsules magnetic resonance imaging photoluminescence magnetic targeting multimodal imaging theranostics silicon microsphere n/a