Free Radical Research in Cancer
Čipak Gašparović, Ana
Free Radical Research in Cancer - Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2020 - 1 electronic resource (192 p.)
Open Access
Cancer is a great challenge to efficient therapy due to biological diversity. Disturbed oxidative homeostasis in cancer cells certainly contributes to differential therapy response. Further, one of the hallmarks of cancer cells is adaptation which includes fine tuning of the cellular metabolic and signalling pathways as well as transcription profiles. There are several factors which contribute to the tumor diversity and therapy response, and oxidative stress is certainly one of them. Changes in oxygen levels due to hypoxia/reoxygenation during tumor growth modulate antioxidative patterns finally supporting increased cell diversity and adaptation to stressing conditions. Additionally, cancer chemotherapy based on ROS production can also induce also adaptation. To counteract these negative effects natural products are often used for their antioxidant activities as well as photodynamic therapy supported by novel chemosensitizers. Understanding of possible pathways which can trigger antioxidant defence at a certain time during cancer development can also provide possible strategies in fighting cancer.
Creative Commons
English
books978-3-03936-089-5 9783039360888 9783039360895
10.3390/books978-3-03936-089-5 doi
Technology: general issues
NQO1 NQO1*2 polymorphism quinone breast cancer menadione lapachone doxorubicin ascorbate oxidative stress reactive oxygen species sperm cancer chemotherapy antioxidant therapy antioxidant proteins chemoresistance oxaliplatin 5-Fluorouracil myelodysplastic syndromes carbonylation deferasirox ovary calcium channel Trolox granulosa cell tumor cell death mitochondria photodynamic therapy singlet oxygen nitric oxide light combination therapy antioxidants bleomycin cancer treatment chemotherapy-induced toxicity cisplatin free radicals methotrexate ozone therapy lung cancer cancer metabolism reactive oxygen species (ROS) therapy resistance new therapeutic strategies breast cancer stem cells 4-hydroxy-2-nonenal extracellular matrix NRF2 bardoxolone methyl prostate cancer castration-resistant prostate cancer androgen receptor (AR), AR-V7 anti-androgen enzalutamide androgen deprivation therapy cancer antioxidant triphala ayurveda chemoprevention and chemotherapy n/a
Free Radical Research in Cancer - Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2020 - 1 electronic resource (192 p.)
Open Access
Cancer is a great challenge to efficient therapy due to biological diversity. Disturbed oxidative homeostasis in cancer cells certainly contributes to differential therapy response. Further, one of the hallmarks of cancer cells is adaptation which includes fine tuning of the cellular metabolic and signalling pathways as well as transcription profiles. There are several factors which contribute to the tumor diversity and therapy response, and oxidative stress is certainly one of them. Changes in oxygen levels due to hypoxia/reoxygenation during tumor growth modulate antioxidative patterns finally supporting increased cell diversity and adaptation to stressing conditions. Additionally, cancer chemotherapy based on ROS production can also induce also adaptation. To counteract these negative effects natural products are often used for their antioxidant activities as well as photodynamic therapy supported by novel chemosensitizers. Understanding of possible pathways which can trigger antioxidant defence at a certain time during cancer development can also provide possible strategies in fighting cancer.
Creative Commons
English
books978-3-03936-089-5 9783039360888 9783039360895
10.3390/books978-3-03936-089-5 doi
Technology: general issues
NQO1 NQO1*2 polymorphism quinone breast cancer menadione lapachone doxorubicin ascorbate oxidative stress reactive oxygen species sperm cancer chemotherapy antioxidant therapy antioxidant proteins chemoresistance oxaliplatin 5-Fluorouracil myelodysplastic syndromes carbonylation deferasirox ovary calcium channel Trolox granulosa cell tumor cell death mitochondria photodynamic therapy singlet oxygen nitric oxide light combination therapy antioxidants bleomycin cancer treatment chemotherapy-induced toxicity cisplatin free radicals methotrexate ozone therapy lung cancer cancer metabolism reactive oxygen species (ROS) therapy resistance new therapeutic strategies breast cancer stem cells 4-hydroxy-2-nonenal extracellular matrix NRF2 bardoxolone methyl prostate cancer castration-resistant prostate cancer androgen receptor (AR), AR-V7 anti-androgen enzalutamide androgen deprivation therapy cancer antioxidant triphala ayurveda chemoprevention and chemotherapy n/a