Prospects for Schistosomiasis Elimination
Gray, Darren
Prospects for Schistosomiasis Elimination - MDPI - Multidisciplinary Digital Publishing Institute 2019 - 1 electronic resource (308 p.)
Open Access
Current efforts to limit the ravages of schistosomiasis are pushing the world closer to eliminating a chronic infection that has been associated with human life in the tropics since time immemorial. This notwithstanding, the disease remains a scourge for large populations in sub-Saharan Africa, Latin America, and Southeast Asia, and the main part of this book is made up by papers dealing with its current distribution, discussing ways and means to establish and implement improved control approaches. While chemotherapy limits the symptoms caused by schistosomiasis, the number of infected people will not decrease until the parasite's life cycle is interrupted. To that end, some papers focus on the intermediate snail host, which is notoriously difficult to control, while others discuss human hygiene and sanitation. The latter approach not only prevents infection through avoiding people being infected from the snail, but more importantly, also stops people infecting the snail by leaving contagious feces and urine in nature. With morbidity reduced by chemotherapy, the immediate target now is the interruption of transmission to be achieved by new tools, such as the novel chemotherapies, improved diagnostics (for humans, animals, and snails), and vaccines discussed in several of the papers. As made clear in this book, a complex infection requires new tools as well as work on many fronts, above all; however, a clear idea is needed as to how to skillfully combine the tools available and sustain implemented control activities.
Creative Commons
English
books978-3-03921-358-0 9783039213580 9783039213573
10.3390/books978-3-03921-358-0 doi
n/a Cambodia schistosomiasis elimination chemotherapy Côte d'Ivoire systems thinking Schistosomiasis mansoni control and elimination neglected tropical diseases drug discovery systems epidemiology guidelines schistosomiasis Central Africa goals mapping Africa cattle zoonosis systematic non-compliance Lao PDR Sm14 POC-CCA planorbidae complexity distribution remote-sensing Neotricula aperta sanitation Biomphalaria glabrata Schistosomiasis international space station Mayuge elimination spatio-temporal epidemiology goats FABP artemether interdisciplinarity praziquantel soil-transmitted-helminthiasis Caribbean health education snail Schistosoma haematobium snail resistance 28S ribosomal DNA WIPO Re:Search intermediate snail host Schistosoma malayensis Gabon transmission soil-transmitted helminths combination therapy S. mansoni climate change domestic animals Schistosoma mansoni diagnosis Schistosoma japonicum leishmaniasis modelling public-private partnerships GIS ECOSTRESS young adults Oncomelania hupensis PCR Bulinus truncatus gene drive worldview S. japonicum zoonosis coverage rate phylogeography cross-sector collaboration epidemiology preventive chemotherapy MDA coverage China operational research transmission control satellite high-sensitivity diagnostics loop-mediated isothermal amplification (LAMP) sheep polymerase chain reaction BIO Ventures for Global Health bovines Kato-Katz vaccine development treatment-opportunities Philippines buffalo Schistosoma mekongi control Schistosoma vector control vaccine parasite Asia transgenic snail snail control DNA capacity-building Uganda pooled samples
Prospects for Schistosomiasis Elimination - MDPI - Multidisciplinary Digital Publishing Institute 2019 - 1 electronic resource (308 p.)
Open Access
Current efforts to limit the ravages of schistosomiasis are pushing the world closer to eliminating a chronic infection that has been associated with human life in the tropics since time immemorial. This notwithstanding, the disease remains a scourge for large populations in sub-Saharan Africa, Latin America, and Southeast Asia, and the main part of this book is made up by papers dealing with its current distribution, discussing ways and means to establish and implement improved control approaches. While chemotherapy limits the symptoms caused by schistosomiasis, the number of infected people will not decrease until the parasite's life cycle is interrupted. To that end, some papers focus on the intermediate snail host, which is notoriously difficult to control, while others discuss human hygiene and sanitation. The latter approach not only prevents infection through avoiding people being infected from the snail, but more importantly, also stops people infecting the snail by leaving contagious feces and urine in nature. With morbidity reduced by chemotherapy, the immediate target now is the interruption of transmission to be achieved by new tools, such as the novel chemotherapies, improved diagnostics (for humans, animals, and snails), and vaccines discussed in several of the papers. As made clear in this book, a complex infection requires new tools as well as work on many fronts, above all; however, a clear idea is needed as to how to skillfully combine the tools available and sustain implemented control activities.
Creative Commons
English
books978-3-03921-358-0 9783039213580 9783039213573
10.3390/books978-3-03921-358-0 doi
n/a Cambodia schistosomiasis elimination chemotherapy Côte d'Ivoire systems thinking Schistosomiasis mansoni control and elimination neglected tropical diseases drug discovery systems epidemiology guidelines schistosomiasis Central Africa goals mapping Africa cattle zoonosis systematic non-compliance Lao PDR Sm14 POC-CCA planorbidae complexity distribution remote-sensing Neotricula aperta sanitation Biomphalaria glabrata Schistosomiasis international space station Mayuge elimination spatio-temporal epidemiology goats FABP artemether interdisciplinarity praziquantel soil-transmitted-helminthiasis Caribbean health education snail Schistosoma haematobium snail resistance 28S ribosomal DNA WIPO Re:Search intermediate snail host Schistosoma malayensis Gabon transmission soil-transmitted helminths combination therapy S. mansoni climate change domestic animals Schistosoma mansoni diagnosis Schistosoma japonicum leishmaniasis modelling public-private partnerships GIS ECOSTRESS young adults Oncomelania hupensis PCR Bulinus truncatus gene drive worldview S. japonicum zoonosis coverage rate phylogeography cross-sector collaboration epidemiology preventive chemotherapy MDA coverage China operational research transmission control satellite high-sensitivity diagnostics loop-mediated isothermal amplification (LAMP) sheep polymerase chain reaction BIO Ventures for Global Health bovines Kato-Katz vaccine development treatment-opportunities Philippines buffalo Schistosoma mekongi control Schistosoma vector control vaccine parasite Asia transgenic snail snail control DNA capacity-building Uganda pooled samples