Peroxiredoxin 6 as a Unique Member of the Peroxiredoxin Family
Fisher, Aron B.
Peroxiredoxin 6 as a Unique Member of the Peroxiredoxin Family - MDPI - Multidisciplinary Digital Publishing Institute 2019 - 1 electronic resource (152 p.)
Open Access
The peroxiredoxin family was discovered approximately 30 years ago and is now recognized as one of the most important families of enzymes related to antioxidant defense and cellular signaling. Peroxiredoxin 6 shares the basic enzymatic functions that characterize this family, but also exhibits several unique and crucial activities. These include the ability to reduce phospholipid hydroperoxides, phospholipase A2 activity, and an acyl transferase activity that is important in phospholipid remodeling. This book describes the available models for investigating the unique functions of PRDX6 and its role in normal physiological function, as well its roles in the pathophysiology of diseases including cancer, diseases of the eye, and male fertility.
Creative Commons
English
books978-3-03897-935-7 9783038979340 9783038979357
10.3390/books978-3-03897-935-7 doi
n/a NADPH (nicotinamide adenine dinucleotide phosphate) oxidase sperm capacitation phospholipid hydroperoxide cornea peroxidase phospholipase A2 1-Cys Prdx knock-in mouse drug delivery antioxidant activity sulfinic acid radioprotection spermatozoa peroxiredoxin 6 mass spectroscopic analysis knockout mouse phospholipase A2 activity liposomes mitochondrial membrane potential lipid peroxidation PLA2 activity ionizing radiation glutathione peroxidase Peroxiredoxin Prdx6 structure membrane repair substrate binding inflammation reactive oxygen species Prdx6 sulfonic/sulfinic acid Fuchs' endothelial corneal dystrophy endothelium fertilization peroxidatic cysteine thioredoxin fold redox balance surfactant protein A diabetes oxidative stress
Peroxiredoxin 6 as a Unique Member of the Peroxiredoxin Family - MDPI - Multidisciplinary Digital Publishing Institute 2019 - 1 electronic resource (152 p.)
Open Access
The peroxiredoxin family was discovered approximately 30 years ago and is now recognized as one of the most important families of enzymes related to antioxidant defense and cellular signaling. Peroxiredoxin 6 shares the basic enzymatic functions that characterize this family, but also exhibits several unique and crucial activities. These include the ability to reduce phospholipid hydroperoxides, phospholipase A2 activity, and an acyl transferase activity that is important in phospholipid remodeling. This book describes the available models for investigating the unique functions of PRDX6 and its role in normal physiological function, as well its roles in the pathophysiology of diseases including cancer, diseases of the eye, and male fertility.
Creative Commons
English
books978-3-03897-935-7 9783038979340 9783038979357
10.3390/books978-3-03897-935-7 doi
n/a NADPH (nicotinamide adenine dinucleotide phosphate) oxidase sperm capacitation phospholipid hydroperoxide cornea peroxidase phospholipase A2 1-Cys Prdx knock-in mouse drug delivery antioxidant activity sulfinic acid radioprotection spermatozoa peroxiredoxin 6 mass spectroscopic analysis knockout mouse phospholipase A2 activity liposomes mitochondrial membrane potential lipid peroxidation PLA2 activity ionizing radiation glutathione peroxidase Peroxiredoxin Prdx6 structure membrane repair substrate binding inflammation reactive oxygen species Prdx6 sulfonic/sulfinic acid Fuchs' endothelial corneal dystrophy endothelium fertilization peroxidatic cysteine thioredoxin fold redox balance surfactant protein A diabetes oxidative stress