Killing Cancer : Discovery and Selection of New Target Molecules
Kallunki, Tuula
Killing Cancer : Discovery and Selection of New Target Molecules - Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2020 - 1 electronic resource (302 p.)
Open Access
Despite the efficiency of current cancer treatments, cancer is still a deadly disease for too many. In 2008, 7.6 million people died of cancer; with the current development, it is estimated that the annual cancer death number will grow to 13 million by 2030. There is clearly a need for not only more research but also more innovative and out of the mainstream scientific ideas to discover and develop even better cancer treatments. This book presents the collective works published in the recent Special Issue entitled "Killing Cancer: Discovery and Selection of New Target Molecules". These articles comprise a selection of studies, ideas, and opinions that aim to facilitate knowledge, thoughts, and discussion about which biological and molecular mechanisms in cancer we should target and how we should target them.
Creative Commons
English
books978-3-03943-441-1 9783039434404 9783039434411
10.3390/books978-3-03943-441-1 doi
Research & information: general
Biology, life sciences
ferlin myoferlin dysferlin otoferlin C2 domain plasma membrane sulconazole NF-κB IL-8 mammosphere breast cancer stem cells AF1Q MLLT11 WNT STAT esophageal cancer prognosis mTORC1 mTORC2 metabolism rapalogs mTOR inhibitors cancer metabolism mTOR in immunotherapy nutrient metabolism kinase inhibitors mTOR signaling MAPK kinase ERK1 ERK2 CD domain Rolled SCH772984 VRT-11E sevenmaker cancer therapy EMT lysosome lysosome-mediated invasion MZF1 phosphorylation PAK4 SUMOylation transcription factor zinc finger glucocorticoids 3D growth nuclear factor kappa-light-chain-enhancer of activated B-cells (NF-κB) epithelial-mesenchymal transition anoikis proliferation targeted cancer therapy disulfiram NPL4 replication stress DNA damage BRCA1 BRCA2 ATR pathway PDAC TCIRG1 ATP6V0a3 invasion migration matrix degradation pH-regulation autophagy multidrug resistance in cancer drug efflux pumps ATP-binding cassette transporter breast cancer resistance protein (BCRP) ABCG2 pyrazolo-pyrimidine derivative SCO-201 colorectal cancer immunotherapy inflammation microsatellite instability oncofetal chondroitin sulfate chondroitin sulfate cancer solid tumors target pediatric cancer VAR2 dexamethasone thyroid cancer microgravity space environment n/a
Killing Cancer : Discovery and Selection of New Target Molecules - Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2020 - 1 electronic resource (302 p.)
Open Access
Despite the efficiency of current cancer treatments, cancer is still a deadly disease for too many. In 2008, 7.6 million people died of cancer; with the current development, it is estimated that the annual cancer death number will grow to 13 million by 2030. There is clearly a need for not only more research but also more innovative and out of the mainstream scientific ideas to discover and develop even better cancer treatments. This book presents the collective works published in the recent Special Issue entitled "Killing Cancer: Discovery and Selection of New Target Molecules". These articles comprise a selection of studies, ideas, and opinions that aim to facilitate knowledge, thoughts, and discussion about which biological and molecular mechanisms in cancer we should target and how we should target them.
Creative Commons
English
books978-3-03943-441-1 9783039434404 9783039434411
10.3390/books978-3-03943-441-1 doi
Research & information: general
Biology, life sciences
ferlin myoferlin dysferlin otoferlin C2 domain plasma membrane sulconazole NF-κB IL-8 mammosphere breast cancer stem cells AF1Q MLLT11 WNT STAT esophageal cancer prognosis mTORC1 mTORC2 metabolism rapalogs mTOR inhibitors cancer metabolism mTOR in immunotherapy nutrient metabolism kinase inhibitors mTOR signaling MAPK kinase ERK1 ERK2 CD domain Rolled SCH772984 VRT-11E sevenmaker cancer therapy EMT lysosome lysosome-mediated invasion MZF1 phosphorylation PAK4 SUMOylation transcription factor zinc finger glucocorticoids 3D growth nuclear factor kappa-light-chain-enhancer of activated B-cells (NF-κB) epithelial-mesenchymal transition anoikis proliferation targeted cancer therapy disulfiram NPL4 replication stress DNA damage BRCA1 BRCA2 ATR pathway PDAC TCIRG1 ATP6V0a3 invasion migration matrix degradation pH-regulation autophagy multidrug resistance in cancer drug efflux pumps ATP-binding cassette transporter breast cancer resistance protein (BCRP) ABCG2 pyrazolo-pyrimidine derivative SCO-201 colorectal cancer immunotherapy inflammation microsatellite instability oncofetal chondroitin sulfate chondroitin sulfate cancer solid tumors target pediatric cancer VAR2 dexamethasone thyroid cancer microgravity space environment n/a