Applications of toxicogenomics in safety evaluation and risk assessment /
Applications of toxicogenomics in safety evaluation and risk assessment /
edited by Darrell R. Boverhof, B. Bhaskar Gollapudi.
- Hoboken, N.J. : John Wiley & Sons, ©2011.
- 1 online resource (xiii, 377 pages) : illustrations
Includes bibliographical references and index.
Toxicology, "omics" technologies, and toxicogenomics : a primer -- Introduction to human health risk assessment -- Practical considerations for the application of toxicogenomics to risk assessment--early experience, current drivers, and a path forward -- Approaches and practical considerations for the analysis of toxicogenomics data -- Genomics in identifying mutagenic mode of action in carcinogenesis -- Application of genomics for predicting and understanding the mode of action for non-genotoxic carcinogens -- Genomics in characterizing endocrine toxicity -- Studying organ specific toxicity using gene expression profiling -- Toxicogenomic studies in human populations -- Toxicogenomics applied to ecological risk assessment -- Analysis of transcriptomic dose response data for toxicology and risk assessment -- Toxicogenomics as a tool for validating animal to human extrapolations in chemical risk assessment: concepts, applications and challenges -- Toxicogenomics and animal alternatives -- Toxicogenomics and the regulatory framework -- Standardization of gene expression information for the safety evaluation--activities in Japan -- -- Applying transcriptional profiling in drug safety evaluation -- Reframing the risk assessment paradigm : towards a systems biology approach.
"This book provides a timely overview of toxicogenomics, with special emphasis on the practical applications of this technology to the risk assessment process. Introductory sections are followed by a series of chapters highlighting practical and systematic applications of toxicogenomics in informing the risk assessment process - including the areas of mutagenicity, carcinogenicity, endocrine toxicity, organ-specific toxicity, population monitoring, and ecotoxicology. The book concludes with approaches for the integration of this technology in safety evaluation studies, and an outlook on how toxicogenomics and complementary technologies can reframe the current risk assessment paradigm"--Provided by publisher.
English.
9781118001042 (electronic bk.) 1118001044 (electronic bk.) 9781118001035 (electronic bk.) 1118001036 (electronic bk.) 9781118008980 (electronic bk.) 1118008987 (electronic bk.) (cloth) (cloth) 1283239663 9781283239660 9786613239662 6613239666
10.1002/9781118001042 Wiley InterScience http://www3.interscience.wiley.com
2010043286
101544260 DNLM
Genetic toxicology.
Toxicity testing.
Health risk assessment.
Risk assessment.
Toxicogenetics
Risk Assessment
Health Status Indicators
Toxicologie génétique.
Risques pour la santé--Évaluation.
Évaluation du risque.
risk assessment.
HEALTH & FITNESS--Diseases--Genetic.
MEDICAL--Genetics.
Genetic toxicology.
Health risk assessment.
Toxicity testing.
Public Health.
Health & Biological Sciences.
Toxicology & Public Health.
Electronic books.
Electronic books.
Electronic resource.
RA1224.3 / .B68 2011eb
616/.042
2011 J-266 QV 38
Includes bibliographical references and index.
Toxicology, "omics" technologies, and toxicogenomics : a primer -- Introduction to human health risk assessment -- Practical considerations for the application of toxicogenomics to risk assessment--early experience, current drivers, and a path forward -- Approaches and practical considerations for the analysis of toxicogenomics data -- Genomics in identifying mutagenic mode of action in carcinogenesis -- Application of genomics for predicting and understanding the mode of action for non-genotoxic carcinogens -- Genomics in characterizing endocrine toxicity -- Studying organ specific toxicity using gene expression profiling -- Toxicogenomic studies in human populations -- Toxicogenomics applied to ecological risk assessment -- Analysis of transcriptomic dose response data for toxicology and risk assessment -- Toxicogenomics as a tool for validating animal to human extrapolations in chemical risk assessment: concepts, applications and challenges -- Toxicogenomics and animal alternatives -- Toxicogenomics and the regulatory framework -- Standardization of gene expression information for the safety evaluation--activities in Japan -- -- Applying transcriptional profiling in drug safety evaluation -- Reframing the risk assessment paradigm : towards a systems biology approach.
"This book provides a timely overview of toxicogenomics, with special emphasis on the practical applications of this technology to the risk assessment process. Introductory sections are followed by a series of chapters highlighting practical and systematic applications of toxicogenomics in informing the risk assessment process - including the areas of mutagenicity, carcinogenicity, endocrine toxicity, organ-specific toxicity, population monitoring, and ecotoxicology. The book concludes with approaches for the integration of this technology in safety evaluation studies, and an outlook on how toxicogenomics and complementary technologies can reframe the current risk assessment paradigm"--Provided by publisher.
English.
9781118001042 (electronic bk.) 1118001044 (electronic bk.) 9781118001035 (electronic bk.) 1118001036 (electronic bk.) 9781118008980 (electronic bk.) 1118008987 (electronic bk.) (cloth) (cloth) 1283239663 9781283239660 9786613239662 6613239666
10.1002/9781118001042 Wiley InterScience http://www3.interscience.wiley.com
2010043286
101544260 DNLM
Genetic toxicology.
Toxicity testing.
Health risk assessment.
Risk assessment.
Toxicogenetics
Risk Assessment
Health Status Indicators
Toxicologie génétique.
Risques pour la santé--Évaluation.
Évaluation du risque.
risk assessment.
HEALTH & FITNESS--Diseases--Genetic.
MEDICAL--Genetics.
Genetic toxicology.
Health risk assessment.
Toxicity testing.
Public Health.
Health & Biological Sciences.
Toxicology & Public Health.
Electronic books.
Electronic books.
Electronic resource.
RA1224.3 / .B68 2011eb
616/.042
2011 J-266 QV 38