Principles of nucleic acid structure /

Neidle, Stephen.

Principles of nucleic acid structure / Stephen Neidle. - 1st ed. - Amsterdam : Boston : Elsevier ; Academic Press, 2008. - 1 online resource (xii, 289 pages) : illustrations

Includes bibliographical references and index.

Methods for Studying Nucleic Acid Structure. -- The building-blocks of DNA and RNA. -- DNA Structure as Observed in Fibres and Crystals. -- DNA-DNA recognition: non-standard and higher-order DNA structures. -- Principles of small molecule-DNA Recognition. -- The RNA structural world. -- Principles of Protein-DNA Recognition. Methods for studying nucleic acid structure -- The building blocks of DNA and RNA -- DNA structure as observed in fibers and crystals -- Nonstandard and higher-order DNA structures : DNA-DNA recognition -- Principles of small molecule-DNA recognition -- RNA structures and their diversity -- Principles of protein-DNA recognition.

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This unique and practical resource provides the most complete and concise summary of underlying principles and approaches to studying nucleic acid structure, including discussion of x-ray crystallography, NMR, molecular modelling, and databases. Its focus is on a survey of structures especially important for biomedical research and pharmacological applications. To aid novices, the book includes an introduction to technical lingo used to describe nucleic acid structure and conformations (roll, slide, twist, buckle, etc.). This completely updated edition features expanded coverage of the latest advances relevant to recognition of DNA and RNA by small molecules and proteins. In particular, the reader will find extensive new discussions on: RNA folding, ribosome structure and antibiotic interactions, DNA quadruplexes, DNA and RNA protein complexes, and short interfering RNA (siRNA). This handy guide ends with a complete list of resources, including relevant online databases and software. * Completely updated with expanded discussion of topics such as RNA folding, ribosome structure and antibiotic interactions, DNA quadruplexes, DNA and RNA protein complexes, and short interfering RNA (siRNA) * Includes a complete list of resources, including relevant online databases and software * Defines technical lingo for novices.


Electronic reproduction.
[Place of publication not identified] :
HathiTrust Digital Library,
2010.


Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002.
http://purl.oclc.org/DLF/benchrepro0212


English.

9780123695079 0123695074 9780080553528 (electronic bk.) 0080553524 (electronic bk.) 1281059374 9781281059376 9786611059378 6611059377

115901:115999 Elsevier Science & Technology http://www.sciencedirect.com

014624832 Uk


Nucleic acids.
Nucleic Acid Conformation
Nucleic Acids
Nucleic Acids--chemistry
Acides nucléiques.
Acides nucléiques--Conformation.
SCIENCE--Chemistry--Organic.
Nucleic acids.
Molekulargenetik


Electronic books.

QD433 / .N43 2008eb

547/.596

QU 58 / N3974p 2008

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